Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: A potent inhibitor of DNA polymerase β and HIV reverse transcriptase
Org Biomol Chem
(2003)
1
1664
(doi: 10.1039/b301676p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORG BIOMOL CHEM
(2003)
1
2807
(doi: 10.1039/b305713e)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
Org. Biomol. Chem.
(2003)
1
3197
(doi: 10.1039/b306861g)
1,5-Asymmetric induction of chirality using π-allyltricarbonyliron lactone complexes: Highly diastereoselective synthesis of α-functionalised carbonyl compounds
Org. Biomol. Chem.
(2003)
1
3208
(doi: 10.1039/b306862e)
A rapid stereocontrolled synthesis of the 3 a -hydroxy-pyrrolo[2,3- b ]indole skeleton, a building block for 10 b -hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3- b ]indole-1,4-diones
Org Biomol Chem
(2003)
1
3492
(doi: 10.1039/b308288a)
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
Microencapsulation of osmium tetroxide in polyurea
Organic letters
(2002)
5
185
(doi: 10.1021/ol020225+)
Analytical techniques for small molecule solid phase synthesis.
Current Medicinal Chemistry
(2002)
9
2103
(doi: 10.2174/0929867023368737)
Benzotriazoles in solid-phase organic chemistry
Chemtracts
(2002)
15
751
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