Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Organic-catalyst-mediated cyclopropanation reaction
Angewandte Chemie International Edition
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: Efficient and chemoselective reduction of aryl ketones
Chem Commun (Camb)
(2003)
3
678
(doi: 10.1039/b300074p)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
Org Biomol Chem
(2003)
1
3263
(doi: 10.1039/b308793j)
COPPER(I)-CATALYZED PREPARATION OF (E)-3-IODOPROP-2-ENOIC ACID
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Development of new synthetic tools for the preparation of biologically active molecules
CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129
235
Synthesis of enantiomers of butane-1,2-diacetal-protected glyceraldehyde and of (R,R)-butane-1,2-diacetal-protected glycolic acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis
Org Biomol Chem
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
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