In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact
M O'Brien, IR Baxendale, SV Ley - Organic Letters (
2010)
12, 1596
(DOI:
10.1021/ol100322t)
Targeting transthyretin - X-ray crystallography and rational drug design
S Kolstoe, AJ Morrison, AJA Cobb, A Coyne, R Gill, MD Smith, SV Ley, SP Wood, MB Pepys - AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2010) 17, 102
Novel palindromic ligands cementing the native quaternary structure of transthyretin
PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys - AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2010) 17, 49
Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor
M Baumann, IR Baxendale, A Kirschning, SV Ley, J Wegner - Heterocycles (
2010)
82, 1297
(DOI:
10.3987/COM-10-S(E)77)
Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor
M Baumann, IR Baxendale, SV Ley - Synlett (
2010)
2010, 749
(DOI:
10.1055/s-0029-1219344)
ReactIR flow cell: A new analytical tool for continuous flow chemical processing
CF Carter, H Lange, SV Ley, IR Baxendale, B Wittkamp, JG Goode, NL Gaunt - Organic Process Research and Development (
2010)
14, 393
(DOI:
10.1021/op900305v)
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT(1B) Antagonist
ZZ Qian, IR Baxendale, SV Ley - Synlett (
2010)
2010, 505
(DOI:
10.1055/s-0029-1219358)
Total synthesis of the anti-apoptotic agents Iso- And bongkrekic acids
A Francais, A Leyva, G Etxebarria-Jardi, SV Ley - Organic Letters (
2010)
12, 340
(DOI:
10.1021/ol902676t)
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-Ones and Their Use in Heterocycle Synthesis
IR Baxendale, SC Schou, J Sedelmeier, SV Ley - Chemistry (
2010)
16, 89
(DOI:
10.1002/chem.200902906)
An Asymmetric Tandem Conjugative Addition-Intramolecular Cyclisation Process to Provide Functionalised 3,6-Dihydropyrans and 4,5-Epoxytetrahydropyrans
S Catalan-Munoz, CA Muller, SV Ley - European Journal of Organic Chemistry (
2010)
2010, 183
(DOI:
10.1002/ejoc.200901145)
