In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Development of fluorination methods using continuous-flow microreactors
M Baumann, IR Baxendale, LJ Martin, SV Ley - Tetrahedron (
2009)
65, 6611
(DOI:
10.1016/j.tet.2009.05.083)
Cancer, chemistry, and the cell: Molecules that interact with the neurotensin receptors
RM Myers, JW Shearman, MO Kitching, A Ramos-Montoya, DE Neal, SV Ley - ACS Chem Biol (
2009)
4, 503
(DOI:
10.1021/cb900038e)
A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
A Palmieri, SV Ley, K Hammond, A Polyzos, IR Baxendale - Tetrahedron Letters (
2009)
50, 3287
(DOI:
10.1016/j.tetlet.2009.02.059)
CHEMICAL SAFETY Mg3N2 EXPLOSION RISK
SV Ley - CHEMICAL & ENGINEERING NEWS (2009) 87, 4
Continuous flow based catch and release protocol for the synthesis of α-ketoesters
A Palmieri, SV Ley, A Polyzos, M Ladlow, IR Baxendale - Beilstein J Org Chem (
2009)
5, 23
(DOI:
10.3762/bjoc.5.23)
A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles
IR Baxendale, CD Buckle, SV Ley, L Tamborini - Synthesis (
2009), 1485
(DOI:
10.1055/s-0028-1087991)
AuCl3-catalyzed hydroalkoxylatlon of conjugated alkynoates: Synthesis of five- and six-membered cyclic acetals
A Dieguez-Vazquez, CC Tzschucke, J Crecente-Campo, S McGrath, SV Ley - European Journal of Organic Chemistry (
2009), 1698
(DOI:
10.1002/ejoc.200801221)
Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis
AC Evans, DA Longbottom, M Matsuoka, JE Davies, R Turner, V Franckevicius, SV Ley - Organic and Biomolecular Chemistry (
2009)
7, 747
(DOI:
10.1039/b813494d)
Total synthesis of the potent antifungal agents bengazole C and E
A Enriquez-Garcia, SV Ley - Collection of Czechoslovak Chemical Communications (
2009)
74, 887
(DOI:
10.1135/cccc2009016)
Total synthesis of (-)-spirangien a and the corresponding methyl ester
PB Cranwell, SV Ley - Chemtracts (2009) 22, 173
