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Professor Sir Alan Fersht FRS

Portrait of arf25

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.
D Bromley, MR Bauer, AR Fersht, V Daggett
– Protein engineering, design & selection : PEDS
(2016)
Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs.
MR Bauer, RN Jones, MGJ Baud, R Wilcken, FM Boeckler, AR Fersht, AC Joerger, J Spencer
– ACS Chem Biol
(2016)
11,
2265
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
AC Joerger, AR Fersht
– Annual Review of Biochemistry
(2016)
85,
375
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.
AC Joerger, MR Bauer, R Wilcken, MGJ Baud, H Harbrecht, TE Exner, FM Boeckler, J Spencer, AR Fersht
– Structure (London, England : 1993)
(2015)
23,
2246
Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.
R Wilcken, MO Zimmermann, MR Bauer, TJ Rutherford, AR Fersht, AC Joerger, FM Boeckler
– ACS Chem Biol
(2015)
10,
2725
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
2443
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
2437
Deconvoluting protein (un)folding structural ensembles using X-ray scattering, nuclear magnetic resonance spectroscopy and molecular dynamics simulation
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
– PLoS One
(2015)
10,
e0125662
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry.
AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
19656
MDMX contains an autoinhibitory sequence element.
M Bista, M Petrovich, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
17814
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Research Interest Group

Email address

arf25@cam.ac.uk