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Yusuf Hamied Department of Chemistry

 

Professor Sir Alan Fersht FRS

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Targeting mutant p53 with PK11007: A new approach for the treatment of patients with triple-negative breast cancer?
NC Synnott, MR Bauer, SF Madden, AM Murray, R Klinger, N O'Donovan, D O'Connor, WM Gallagher, J Crown, AR Fersht, MJ Duffy
– Journal of Clinical Oncology
(2017)
35,
e14099
(doi: 10.1200/JCO.2017.35.15_suppl.e14099)
Structures of closed and open conformations of dimeric human ATM
D Baretić, HK Pollard, DI Fisher, CM Johnson, B Santhanam, CM Truman, T Kouba, AR Fersht, C Phillips, RL Williams
– Sci Adv
(2017)
3,
e1700933
(doi: 10.1126/sciadv.1700933)
Multisite aggregation of p53 and implications for drug rescue
GZ Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E2634
(doi: 10.1073/pnas.1700308114)
Multisite aggregation of p53 and implications for drug rescue
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences
(2017)
114,
e2634
(doi: 10.1073/pnas.1700308114)
Design of a molecular support for cryo-EM structure determination
TG Martin, TAM Bharat, AC Joerger, X-C Bai, F Praetorius, AR Fersht, H Dietz, SHW Scheres
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
E7456
(doi: 10.1073/pnas.1612720113)
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
MR Bauer, AC Joerger, AR Fersht
– Proceedings of the National Academy of Sciences
(2016)
113,
e5271
(doi: 10.1073/pnas.1610421113)
An in silico algorithm for identifying stabilizing pockets in proteins: Test case, the Y220C mutant of the p53 tumor suppressor protein
D Bromley, MR Bauer, AR Fersht, V Daggett
– Protein Eng Des Sel
(2016)
29,
377
(doi: 10.1093/protein/gzw035)
Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
MR Bauer, RN Jones, MGJ Baud, R Wilcken, FM Boeckler, AR Fersht, AC Joerger, J Spencer
– ACS chemical biology
(2016)
11,
2265
(doi: 10.1021/acschembio.6b00315)
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
AC Joerger, AR Fersht
– Annual Review of Biochemistry
(2016)
85,
1
(doi: 10.1146/annurev-biochem-060815-014710)
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.
AC Joerger, MR Bauer, R Wilcken, MGJ Baud, H Harbrecht, TE Exner, FM Boeckler, J Spencer, AR Fersht
– Structure (London, England : 1993)
(2015)
23,
2246
(doi: 10.1016/j.str.2015.10.016)
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