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  • Currently displaying 61 - 80 of 229 publications
Single-molecule fluorescence detection of a tricyclic nucleoside analogue.
GN Samaan, MK Wyllie, JM Cizmic, L-M Needham, D Nobis, K Ngo, S Andersen, SW Magennis, SF Lee, BW Purse
– Chemical science
(2020)
12,
2623
(doi: 10.1039/d0sc03903a)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
A Vilalta, Y Zhou, J Sevalle, J Griffin, K Satoh, D Allendorf, S De, M Puigdellívol, A Bruzas, M Burguillos, R Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, P Fraser, D Klenerman, S Lee, P St George-Hyslop, G Brown
(2020)
(doi: 10.1101/2020.12.03.409995)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(doi: 10.21203/rs.3.rs-81521/v1)
vLUME: 3D Virtual Reality for Single-molecule Localization Microscopy
S Lee, A Handa, L-M Needham, A Carr, A Ponjavic, J McColl
– Nature methods
(2020)
17,
1097
(doi: 10.1038/s41592-020-0962-1)
A Comparative Photophysical Study of Structural Modifications of Thioflavin T‑Inspired Fluorophores
L-M Needham, J Weber, CM Pearson, DT Do, F Gorka, G Lyu, SE Bohndiek, TN Snaddon, SF Lee
– J Phys Chem Lett
(2020)
11,
8406
(doi: 10.1021/acs.jpclett.0c01549)
Single Molecule Light Field Microscopy
RR Sims, SA Rehman, MO Lenz, SI Benaissa, E Bruggeman, A Clark, EW Sanders, A Ponjavic, L Muresan, SF Lee, K O’Holleran
– Optica
(2020)
7,
1065
(doi: 10.1364/OPTICA.397172)
Single-molecule visualisation of DNA G-quadruplex formation in live cells.
M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian
– Nature chemistry
(2020)
12,
832
(doi: 10.1038/s41557-020-0506-4)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2020)
117,
13509
(doi: 10.1073/pnas.1919464117)
Data analysis in transient electronic spectroscopy – an experimentalist's view
JS Beckwith, CA Rumble, E Vauthey
– International Reviews in Physical Chemistry
(2020)
39,
135
(doi: 10.1080/0144235X.2020.1757942)
Distinct domain requirements for EAP45 in HIV budding, late endosomal recruitment, and cytokinesis
B Meng, P Vallejo Ramirez, K Scherer, E Bruggeman, J Kenyon, C Kaminski, A Lever
– bioRxiv
(2020)
2020.05.23.112607
(doi: 10.1101/2020.05.23.112607)
Single Molecule Light Field Microscopy
R Sims, S Abdul Rehman, M Lenz, A Clark, E Sanders, A Ponjavic, L Muresan, S Lee, K O’Holleran
(2020)
2020.05.20.104802
(doi: 10.1101/2020.05.20.104802)
ThX-a next-generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, L Tutton, R Cliffe, B Keenlyside, D Klenerman, CM Dobson, CA Hunter, KH Müller, K O'Holleran, SE Bohndiek, TN Snaddon, SF Lee
– Chemical science
(2020)
11,
4578
(doi: 10.1039/c9sc04730a)
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, G Brown, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– BioRxiv
(2020)
2020.04.03.003178
(doi: 10.1101/2020.04.03.003178)
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.
K Kulenkampff, AH Lippert, J McColl, AM Santos, A Ponjavic, E Jenkins, J Humphrey, A Winkel, K Franze, SF Lee, SJ Davis, D Klenerman
– Biophysical Journal
(2020)
118,
1261
(doi: 10.1016/j.bpj.2020.01.019)
vLUME: 3D Virtual Reality for Single-molecule Localization Microscopy
A Spark, A Kitching, D Esteban-Ferrer, A Handa, A Carr, L-M Needham, A Ponjavic, MDC Santos, J McColl, C Leterrier, S Davis, R Henriques, S Lee
(2020)
2020.01.20.912733
(doi: 10.1101/2020.01.20.912733)
Hemidesmosomes modulate force generation via focal adhesions
W Wang, A Zuidema, L Te Molder, L Nahidiazar, L Hoekman, T Schmidt, S Coppola, A Sonnenberg
– Journal of Cell Biology
(2020)
219,
e201904137
(doi: 10.1083/jcb.201904137)
Modular actin nano-architecture enables podosome protrusion and mechanosensing
K van den Dries, L Nahidiazar, JA Slotman, MBM Meddens, E Pandzic, B Joosten, M Ansems, J Schouwstra, A Meijer, R Steen, M Wijers, J Fransen, AB Houtsmuller, PW Wiseman, K Jalink, A Cambi
– Nature Communications
(2019)
10,
5171
(doi: 10.1038/s41467-019-13123-3)
ThX – A next-generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, D Klenerman, CM Dobson, CA Hunter, SE Bohndiek, TN Snaddon, SF Lee
– BIOPHYSICAL JOURNAL
(2019)
121,
19
(doi: 10.1101/713594)
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
– Proceedings of the National Academy of Sciences
(2019)
116,
14002
(doi: 10.1073/pnas.1817255116)
Ion-Pair Dynamics upon Photoinduced Electron Transfer Monitored by Pump-Pump-Probe Spectroscopy.
JS Beckwith, B Lang, J Grilj, E Vauthey
– Journal of Physical Chemistry Letters
(2019)
10,
3688
(doi: 10.1021/acs.jpclett.9b01431)

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