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It is the long history of humankind (and animal kind, too) those who learned to collaborate and improvise most effectively have prevailed.” 


Our lab concentrates on solving problems for the most important biological problems, as such we build extensive collaborations with other labs:

 

Prof Sir David Klenerman, FRS (Chemistry, Cambridge). Single-molecule light sheet microscopy.

Prof Simon Davis (Weatherall Institute for Molecular Medicine, Oxford). Molecular Origin of Human Adaptive immunity.

Prof Andres Floto (Laboratory of Molecule Biology, LMB, Cambridge). Single-molecule K-Ras signalling in Cancer.

Dr David Gershlick (Cambridge Institute for Medical Research, CIMR, Cambridge). Golgi-mediated protein sorting. 

Prof Tom Snaddon (Chemistry, Indiana, USA). Novel fluorophore development.

Prof Nicholas Wood (Institute for Neurology, UCL). New tools for visualising oligomer in Parkinson’s Disease. 

Prof Nick Evans (Bioengineering, Southampton). Single-molecule Wnt3a dynamics. 

Dr Kevin O’Holleran (Cambridge Advanced Imaging Centre, Cambridge). 3D Super-Resolution Imaging development.

Dr Amalio Fernandez-Pacheco (Physics, Glasgow). 3D nanostructures for biological imaging.

Prof Sonia Gandhi (The Crick Institute, London). Structurally specific immunoprecipitation in human spinal fluid.

 

Recent Publications

Vortex Light Field Microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, LM Needham, R Peters, SF Lee, K O’Holleran
– Optica
(2024)
11,
1519
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, S Grant, M Horrocks, S Lee
(2024)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nat Methods
(2024)
21,
1873
Single-Molecule Sensitivity in Hot Microcavities in the Unstable Regime
CA Saavedra Salazar, D Sole-Barber, N Asgari, B Cullinane, L-M Needham, J Rasch, M Reitz, S Wan, J Yuen-Zhou, R Goldsmith
(2024)
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
– Nature Communications
(2024)
15,
7740