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It is the long history of humankind (and animal kind, too) those who learned to collaborate and improvise most effectively have prevailed.” 


Our lab concentrates on solving problems for the most important biological problems, as such we build extensive collaborations with other labs:

 

Prof Sir David Klenerman, FRS (Chemistry, Cambridge). Single-molecule light sheet microscopy.

Prof Simon Davis (Weatherall Institute for Molecular Medicine, Oxford). Molecular Origin of Human Adaptive immunity.

Prof Andres Floto (Laboratory of Molecule Biology, LMB, Cambridge). Single-molecule K-Ras signalling in Cancer.

Dr David Gershlick (Cambridge Institute for Medical Research, CIMR, Cambridge). Golgi-mediated protein sorting. 

Prof Tom Snaddon (Chemistry, Indiana, USA). Novel fluorophore development.

Prof Nicholas Wood (Institute for Neurology, UCL). New tools for visualising oligomer in Parkinson’s Disease. 

Prof Nick Evans (Bioengineering, Southampton). Single-molecule Wnt3a dynamics. 

Dr Kevin O’Holleran (Cambridge Advanced Imaging Centre, Cambridge). 3D Super-Resolution Imaging development.

Dr Amalio Fernandez-Pacheco (Physics, Glasgow). 3D nanostructures for biological imaging.

Prof Sonia Gandhi (The Crick Institute, London). Structurally specific immunoprecipitation in human spinal fluid.

 

Recent Publications

Single-Molecule Stoichiometry of Supramolecular Complexes.
A McLean, RL Sala, BW Longbottom, AR Carr, JA McCune, SF Lee, OA Scherman
– Journal of the American Chemical Society
(2024)
146,
12877
Label-free detection and profiling of individual solution-phase molecules.
L-M Needham, C Saavedra, JK Rasch, D Sole-Barber, BS Schweitzer, AJ Fairhall, CH Vollbrecht, S Wan, Y Podorova, AJ Bergsten, B Mehlenbacher, Z Zhang, L Tenbrake, J Saimi, LC Kneely, JS Kirkwood, H Pfeifer, ER Chapman, RH Goldsmith
– Nature
(2024)
629,
1062
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
– J Phys Chem B
(2024)
128,
3585
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
– Nature Communications
(2024)
15,
1940
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
– Nat Commun
(2024)
15,
1940