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Dr Lisa-Maria Needham

Project: Developing new fluorophores for super-resolution and single-molecule fluorescence Imaging.

Publications

ThX: a next generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, D Klenerman, CM Dobson, CA Hunter, SE Bohndiek, TN Snaddon, SF Lee
– Biophysical Journal
(2022)
121,
19a
(doi: 10.1016/j.bpj.2021.11.2608)
A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue.
F Gorka, CM Pearson, E Bulovaite, YP Zhang, A Handa, SGN Grant, TN Snaddon, LM Needham, SF Lee
– The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter
(2021)
125,
13710
(doi: 10.1021/acs.jpcb.1c07762)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation
A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown
– J Biol Chem
(2021)
296,
100631
(doi: 10.1016/j.jbc.2021.100631)
Single-molecule fluorescence detection of a tricyclic nucleoside analogue
GN Samaan, MK Wyllie, JM Cizmic, L-M Needham, D Nobis, K Ngo, S Andersen, SW Magennis, SF Lee, BW Purse
– Chem Sci
(2020)
12,
2623
(doi: 10.1039/d0sc03903a)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
A Vilalta, Y Zhou, J Sevalle, J Griffin, K Satoh, D Allendorf, S De, M Puigdellívol, A Bruzas, M Burguillos, R Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, P Fraser, D Klenerman, S Lee, P St George-Hyslop, G Brown
(2020)
(doi: 10.1101/2020.12.03.409995)
vLUME: 3D virtual reality for single-molecule localization microscopy.
S Lee, A Handa, L-M Needham, A Carr, A Ponjavic, J McColl
– Nat Methods
(2020)
17,
1097
(doi: 10.1038/s41592-020-0962-1)
A Comparative Photophysical Study of Structural Modifications of Thioflavin T‑Inspired Fluorophores
L-M Needham, J Weber, CM Pearson, DT Do, F Gorka, G Lyu, SE Bohndiek, TN Snaddon, SF Lee
– Journal of Physical Chemistry Letters
(2020)
11,
8406
(doi: 10.1021/acs.jpclett.0c01549)
Single-molecule visualization of DNA G-quadruplex formation in live cells
M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian
– Nature Chemistry
(2020)
12,
832
(doi: 10.1038/s41557-020-0506-4)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proc Natl Acad Sci U S A
(2020)
117,
13509
(doi: 10.1073/pnas.1919464117)
ThX-a next-generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, L Tutton, R Cliffe, B Keenlyside, D Klenerman, CM Dobson, CA Hunter, KH Müller, K O'Holleran, SE Bohndiek, TN Snaddon, SF Lee
– Chemical Science
(2020)
11,
4578
(doi: 10.1039/c9sc04730a)
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Telephone number

01223 336410 (shared)

Email address

College

Girton College

    Study at Cambridge

    About the University

    Research at Cambridge