skip to content
Home

TheLeeLab

Dr Lisa-Maria Needham

Project: Developing new fluorophores for super-resolution and single-molecule fluorescence Imaging.

Publications

The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection
CA Saavedra Salazar, D Sole-Barber, S Wan, JK Rasch, M Reitz, B Cullinane, N Asgari, L-M Needham, J Yuen-Zhou, RH Goldsmith
– ACS Nano
(2025)
19,
6342
(doi: 10.1021/acsnano.4c16276)
POLCAM: instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nature Methods
(2024)
21,
1873
(doi: 10.1038/s41592-024-02382-8)
Single-Molecule Sensitivity in Hot Microcavities in the Unstable Regime
CA Saavedra Salazar, D Sole-Barber, N Asgari, B Cullinane, L-M Needham, J Rasch, M Reitz, S Wan, J Yuen-Zhou, R Goldsmith
(2024)
(doi: 10.26434/chemrxiv-2024-xgtxg)
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
(2024)
(doi: 10.1101/2024.07.18.604091)
Label-free detection and profiling of individual solution-phase molecules
L-M Needham, C Saavedra, JK Rasch, D Sole-Barber, BS Schweitzer, AJ Fairhall, CH Vollbrecht, S Wan, Y Podorova, AJ Bergsten, B Mehlenbacher, Z Zhang, L Tenbrake, J Saimi, LC Kneely, JS Kirkwood, H Pfeifer, ER Chapman, RH Goldsmith
– Nature
(2024)
629,
1062
(doi: 10.1038/s41586-024-07370-8)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, C Toomey, J Breiter, J Lachica, R Tian, J Beckwith, L-M Needham, G Chant, C Loiseau, A Deconfin, K Baspin, P Magill, Z Jaunmuktane, O Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, N Wood, L Weiss, S Gandhi, S Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Beyond Labels: Advancing Single Molecule Sensitivity with Hot Fabry-Perot Micro Cavities
C Saavedra, D Sole-Barber, J Rasch, LM Needham, R Goldsmith
– CLEO 2024
(2024)
29,
sf2a.4
(doi: 10.1364/cleo_si.2024.sf2a.4)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature Structural & Molecular Biology
(2023)
31,
390
(doi: 10.1038/s41594-023-01179-1)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature structural & molecular biology
(2023)
30,
1628
(doi: 10.1038/s41594-023-01095-4)
Label-free observation of individual solution phase molecules.
L-M Needham, C Saavedra, JK Rasch, D Sole-Barber, BS Schweitzer, AJ Fairhall, CH Vollbrecht, B Mehlenbacher, Z Zhang, L Tenbrake, H Pfeifer, ER Chapman, RH Goldsmith
– bioRxiv
(2023)
4,
2023.03.24.534170
(doi: 10.1101/2023.03.24.534170)
  • 1 of 4
  • >

Visitor

Telephone number

01223 336410 (shared)

Email address

College

Girton College

    Study at Cambridge

    About the University

    Research at Cambridge