Yusuf Hamied Department of Chemistry

Tim Chisholm

Junior Research Fellow

Publications

Expressed Protein Ligation in Flow
L Kambanis, A Ayoub, MJ Bedding, PHG Egelund, JWC Maxwell, C Franck, L Lambrechts, PME Hawkins, TS Chisholm, JP Mackay, E Sierecki, Y Gambin, SS Kulkarni, RJ Payne
J Am Chem Soc
(2024)
146
(doi: 10.1021/jacs.4c07462)
Ligand Profiling as a Diagnostic Tool to Differentiate Patient- Derived α-Synuclein Polymorphs
C Hunter, T Chisholm, R Melki
ACS chemical neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00178)
A closer look at amyloid ligands, and what they tell us about protein aggregates
TS Chisholm, CA Hunter
Chemical Society reviews
(2024)
53
(doi: 10.1039/d3cs00518f)
Ligand profiling to characterise different polymorphic forms of α-synuclein aggregates.
TS Chisholm, CA Hunter
Journal of the American Chemical Society
(2023)
145
(doi: 10.1021/jacs.3c10521)
Discovery of high-affinity amyloid ligands using a ligand-based vir- tual screening pipeline.
TS Chisholm, M Mackey, CA Hunter
Journal of the American Chemical Society
(2023)
145
(doi: 10.1021/jacs.3c03749)
Ligands as Structural Probes for Amyloid Fibrils
TS Chisholm
(2023)
(doi: 10.17863/CAM.102241)
Rapid one-pot iterative diselenide–selenoester ligation using a novel coumarin-based photolabile protecting group
L Kambanis, TS Chisholm, SS Kulkarni, RJ Payne
Chem Sci
(2021)
12
(doi: 10.1039/d1sc02781f)
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
E Sanna, M Rodrigues, SG Fagan, TS Chisholm, K Kulenkampff, D Klenerman, MG Spillantini, FI Aigbirhio, CA Hunter
Chemical science
(2021)
12
(doi: 10.1039/d1sc01263k)
Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation
TS Chisholm, SS Kulkarni, KR Hossain, F Cornelius, RJ Clarke, RJ Payne
J Am Chem Soc
(2019)
142
(doi: 10.1021/jacs.9b12558)
Native Chemical Ligation-Photodesulfurization in Flow.
TS Chisholm, D Clayton, LJ Dowman, J Sayers, RJ Payne
Journal of the American Chemical Society
(2018)
140
(doi: 10.1021/jacs.8b03115)

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01223 336710

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tsc42@cam.ac.uk

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Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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