Groups: Glen group website
Telephone:
01223 763076 (fax)
01223 336472
E-mail: rcg28@cam.ac.uk
My current position is Professor of Molecular Sciences Informatics and Director of The Unilever Centre for Molecular Sciences Informatics. The Unilever Centre for Molecular Informatics was established as part of the Department of Chemistry to exploit the enormous growth in the availability of scientific data. We are generating and assimilating data from sources world-wide to create new ways of linking and analyzing data to extract knowledge that can lead to a deeper understanding of molecules and their properties. The aim of our research is to devise new methods of creating, searching, manipulating and storing molecular data such that scientists can devise experiments ‘in-silico’ which can be tested both in the computer and in the lab.
The Centre undertakes research projects that span Academic and Industrial Research. The research is hypothesis driven and aimed at collaborative approaches to problem solving with other academic groups, institutes and industrial research groups.This leads to multidisciplinary approaches that exploit molecular data to generate new insights into the properties of molecules and materials.
Molecular Informatics covers the whole gamut of scientific information, and this is reflected in the wide range of projects that are undertaken. Three areas are of particular interest: proteins and ligands, molecular data and chemical tools.
There is a strong interest in the development of novel molecular property calculations and data analysis methods combined with the simulation of biomolecules and materials. Current research interests include drug discovery methods (SAR, simulation of biomolecules and ADME) and molecular data analysis (complexity analysis, new kernel-based data classifiers) as well as drug discovery projects against specific targets.
Career highlights
I gained my Ph.D. (supervisor Prof. Peter Murray-Rust) in X-ray Crystallography, computational chemistry and Organic Synthesis from the University of Stirling. One of the highlights was the first co-crystallisation of a reactant and product of a chemical reaction in a single crystal.
At the Wellcome Foundation I guided the development of the Computer-aided Molecular Design group. This included Protein Crystallography, Molecular Transport properties and Electrochemistry. I designed the GASP and GOLD computer programs (a BBSRC funded grant, which has over 2000 citations) which are used extensively in the pharmaceutical industry, I am a co-inventor of Zomig (a drug for migraine with ca. $5B in sales) and invented two other compounds that have entered Phase-2 clinical development.
I then became Vice President for Collaborative Research at Tripos Inc., a biotechnology company in St. Louis Mo. I assisted in setting up three biotechnology companies (Arena Pharmaceuticals, Phase-1 Molecular Toxicology and Signase). I obtained and directed a BBSRC grant of £2.1M with University College London (discovering activators of soluble guanylate cyclise and working with The Technology Partnership to develop the Baseplate robot) and managed collaborative research and contract research in drug discovery with many large Pharmaceutical companies. Two of the research programs have compounds in early stage studies in Obesity and Artherosclerosis.
In 1999 I moved to the University of Cambridge as Director of the Unilever Centre, a new £15m institute as part of the Chemistry department, which I have built to over forty research scientists. I have published over 120 papers, have numerous patents and am regularly invited to present plenary and other invited lectures.
I have served as deputy chairman of Lhasa Ltd., on the Science Advisory Board of a number of biotechnology companies and international academic advisory and grant awarding bodies (Netherlands Genomics Initiative, NIH Roadmap), on the editorial board of Journal of Chemical Information and Modelling and the Encyclopaedia of Computational Chemistry, a fellow of the Royal Society of Chemistry and a member of the publication board and chair of the IT committee, an honorary fellow of the American Association for Cancer Research and a Fellow of Clare College Cambridge. I have been a consultant to Pfizer, Teva, IDBS, Tripos, Unilever, AstraZeneca, Boehringer Ingelheim, Lhasa Ltd. Inpharmatica, Tripos, Pharmacia, Arrow Therapeutics. I have additionally received over £6M in grants over the last ten years, from EPSRC, BBSRC, DTI and Pharmaceutical and software companies.
I provide a lecture course to second year students on molecular informatics. I supervise PhD students in the Unilever Centre here in Cambridge, and examine 3-4 PhD theses each year.
I generally run two conferences each year. In 2008-9 we have had workshops on ‘in silico toxicology’ (120 attendees) and a workshop on ‘chemistry in toxicology’ (50 attendees).
In 2008 I gave lectures at AstraZeneca, Sweden; Portsmouth University; European Bioinformatics Institute; Warwick University; US National Science Foundation, Washington; Boehringer Ingelheim, Germany; Biomolecular Screening, St. Louis USA; Organon/SP Netherlands; Eisai London; Unilever Corporate Research, Colworth; Royal Society of Chemistry, London; PhysChem Forum, London; Cheminformatics Summer School, Obernai; German Chemical Society; Scherring Plough, USA.
I’m a keen ‘biker’ with a Yamaha Fazer that I blast around Suffolk at weekends. I’m also into Scuba diving, with over 150 dives around the world (my favourite is ‘'superman's flight'’ in St. Lucia). I relax fighting nature in the garden and I’m trying to plant at least five trees a year to save the planet. I travel frequently in my job, with lectures every few months somewhere abroad and I enjoy travel immensely, particularly when I can work closely with local scientists.
The Unilever Centre for Molecular Sciences Informatics receives substantial support from Unilever including an established chair of Molecular Informatics, three lecturers and teaching and research costs. Much of our funding comes from Academic/Industrial collaborations, with many pharmaceutical, chemical and software companies supporting our research. Research councils support a variety of fundamental scientific projects.
We are very grateful to all our funders, particularly Unilever.