Professor David Spring

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors

S Collins, LV Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, C Kaminski, D Spring, F Hollfelder, GSK Schierle

(2022)

(doi: 10.21203/rs.3.rs-1478521/v1)

A unifiedin vitrotoin vivofluorescence lifetime screening platform yields amyloid β aggregation inhibitors

S Collins, L van Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, CF Kaminski, DR Spring, F Hollfelder, GSK Schierle

(2022)

(doi: 10.1101/2022.03.28.485913)

Development of cyclic peptides for the inhibition of intracellular protein-protein interactions

E Atkinson

(2022)

(doi: 10.17863/cam.87069)

Development of small cyclic peptides targeting the CK2α/β interface

E Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvonen, D Spring

(2022)

(doi: 10.26434/chemrxiv-2022-rfxnd)

Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability

SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring

Chem Commun (Camb)

(2022)

1962

(doi: 10.1039/d1cc06766d)

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions (vol 50, pg 7820, 2021)

BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring

Chemical Society Reviews

(2022)

792

(doi: 10.1039/d1cs90109e)

Energetics of lipid transport by the ABC transporter MsbA is lipid dependent.

D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen

Communications Biology

(2021)

1379

(doi: 10.1038/s42003-021-02902-8)

Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.

G Fumagalli, RJ Carbajo, JWM Nissink, J Tart, R Dou, AP Thomas, DR Spring

Journal of medicinal chemistry

(2021)

17287

(doi: 10.1021/acs.jmedchem.1c01334)

Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes.

M Bourdon, J Gaynord, KH Müller, G Evans, S Wallis, P Aston, DR Spring, R Wightman

BMC Plant Biology

(2021)

258

(doi: 10.1186/s12870-021-03010-9)

Rapid and robust cysteine bioconjugation with vinylheteroarenes.

H Seki, SJ Walsh, JD Bargh, JS Parker, J Carroll, DR Spring

Chemical Science

(2021)

9060

(doi: 10.1039/d1sc02722k)

Professor David Spring

Professor of Chemistry & Chemical Biology

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

Teaching

Publications

Publications

Research Group

Research Interest Groups

Telephone number

Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge