Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
Chemical science
(2022)
13
(doi: 10.1039/d2sc02198f)
Reconstructing the history of helminth prevalence in the UK
H Ryan, PG Flammer, R Nicholson, L Loe, B Reeves, E Allison, C Guy, IL Doriga, T Waldron, D Walker, C Kirchhelle, G Larson, AL Smith
PLoS Negl Trop Dis
(2022)
16
(doi: 10.1371/journal.pntd.0010312)
Development of small cyclic peptides targeting the CK2α/β interface
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
Chemical communications (Cambridge, England)
(2022)
58
(doi: 10.1039/d2cc00707j)
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
S Collins, LV Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, C Kaminski, D Spring, F Hollfelder, GSK Schierle
(2022)
(doi: 10.21203/rs.3.rs-1478521/v1)
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
S Collins, L van Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, CF Kaminski, DR Spring, F Hollfelder, GSK Schierle
(2022)
(doi: 10.1101/2022.03.28.485913)
Development of cyclic peptides for the inhibition of intracellular protein-protein interactions
E Atkinson
(2022)
(doi: 10.17863/cam.87069)
Development of small cyclic peptides targeting the CK2α/β interface
E Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvonen, D Spring
(2022)
(doi: 10.26434/chemrxiv-2022-rfxnd)
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2022)
58
(doi: 10.1039/d1cc06766d)
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
Chemical Society reviews
(2022)
51
(doi: 10.1039/d1cs90109e)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen
Commun Biol
(2021)
4
(doi: 10.1038/s42003-021-02902-8)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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