In order to be functional, most proteins have to associate with other proteins to form complexes, the molecular machinery of life. Moreover, incorrectly formed complexes are associated with a range of disorders, including Alzheimer's and Parkinson's diseases. This supra-molecular behaviour of proteins is thus increasingly viewed as a key new frontier in biophysical chemistry, but one which is challenging to probe using conventional methods.
This talk will describe the development and application of new biophysical methods for the study of protein behaviour, and how physical chemistry can make a significant contribution to protein science both through the development of novel measurement and analysis approaches.
RELEVANT PAPER
Latent Analysis of Unmodified Bomolecules and their Complexes in Solution with Attomole Detection Sensitivity Nature Chem. 2015, 7, 802.
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