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Postgraduate Admissions

 

Professor David Spring

Graduate Research in the Spring Group

Our research interests use organic synthesis to make small molecules, which can be utilized to understand and exploit biological systems. Our current projects include diversity-oriented synthesis; synthetic methodology; protein-protein interactions; quorum sensing; new antibiotics and next generation therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of our group members in organic synthesis is given a high priority. All of our graduate students are also encouraged also to learn new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

RELEVANT PAPERS

Protein Modification via Akyne Hydrosilylation using a Substoichiometric Amount of Ruthenium(II) Catalyst Chem. Sci. 20178, 3871.

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase J. Am. Chem. Soc2017139, 2245.

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer Angew. Chem. Int. Ed201756, 524.

A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles Angew. Chem. Int. Ed. 201655, 11139.

spring@ch.cam.ac.uk
T  01223 336498
W  www-spring.ch.cam.ac.uk