Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy
– J R Soc Interface
(2010)
8,
282
(doi: 10.1098/rsif.2010.0238)
Fullerene-based one-dimensional crystalline nanopolymer formed through topochemical transformation of the parent nanowire
– Physical Review B - Condensed Matter and Materials Physics
(2010)
81,
214114
(doi: 10.1103/physrevb.81.214114)
Fullerene-based one-dimensional crystalline nanopolymer formed through topochemical transformation of the parent nanowire
– Physical Review B
(2010)
81,
214114
(doi: 10.1103/physrevb.81.214114)
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment.
– European Journal of Pharmaceutics and Biopharmaceutics
(2010)
76,
120
(doi: 10.1016/j.ejpb.2010.05.013)
Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice
– Physiological Genomics
(2010)
41,
224
Ion- and Liquid-Assisted Grinding: Improved Mechanochemical Synthesis of Metal-Organic Frameworks Reveals Salt Inclusion and Anion Templating
– Angew Chem Int Ed Engl
(2010)
49,
712
(doi: 10.1002/anie.200906583)
Glycosaminoglycans and lipids in vascular calcification: New insights into mineralogenesis from NMR spectroscopy
– European Cells and Materials
(2010)
19,
5
Calcium phosphate mineralization in phosphatic brachiopods, and vertebrates
– European Cells and Materials
(2010)
19,
10
Kidney stone composition by solid state NMR (SSNMR)
– European Cells and Materials
(2010)
19,
12
The Mineral Phase of Calcified Cartilage: Its Molecular Structure and Interface with the Organic Matrix
– Biophysical Journal
(2009)
96,
3372
(doi: 10.1016/j.bpj.2008.12.3954)
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