Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Lipids in biocalcification: contrasts and similarities between intimal and medial vascular calcification and bone by NMR.
– J Lipid Res
(2012)
53,
1569
(doi: 10.1194/jlr.M026088)
Characterization of the phosphatic mineral of the barnacle Ibla cumingi at atomic level by solid-state nuclear magnetic resonance: comparison with other phosphatic biominerals.
– Journal of the Royal Society, Interface
(2012)
9,
1510
(doi: 10.1098/rsif.2011.0895)
A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents
– Green Chemistry
(2012)
14,
2462
(doi: 10.1039/c2gc35799b)
Collagen atomic scale molecular disorder in ochronotic cartilage from an alkaptonuria patient, observed by solid state NMR
– Journal of Inherited Metabolic Disease
(2011)
34,
1137
(doi: 10.1007/s10545-011-9373-x)
Mechanosynthesis of the metallodrug bismuth subsalicylate from Bi2O3 and structure of bismuth salicylate without auxiliary organic ligands.
– Angewandte Chemie (International ed. in English)
(2011)
50,
7858
(doi: 10.1002/anie.201103171)
Effect of Fluorination on Molecular Conformation in the Solid State: Tuning the Conformation of Cocrystal Formers
– Crystal Growth and Design
(2011)
11,
972
(doi: 10.1021/cg1016388)
Tannin Fingerprinting in Vegetable Tanned Leather by Solid State NMR Spectroscopy and Comparison with Leathers Tanned by Other Processes
– Molecules (Basel, Switzerland)
(2011)
16,
1240
(doi: 10.3390/molecules16021240)
Apatite in kidney stones is a molecular composite with glycosaminoglycans and proteins: evidence from nuclear magnetic resonance spectroscopy, and relevance to Randall's plaque, pathogenesis and prophylaxis.
– The Journal of urology
(2010)
185,
725
(doi: 10.1016/j.juro.2010.09.075)
Towards an environmentally-friendly laboratory: Dimensionality and reactivity in the mechanosynthesis of metal-organic compounds
– Chemical communications (Cambridge, England)
(2010)
46,
9191
(doi: 10.1039/c0cc03822a)
NMR of biopolymer-apatite composites: Developing a model of the molecular structure of the mineral-matrix interface in calcium phosphate biomaterials
– Chemistry of Materials
(2010)
22,
6109
(doi: 10.1021/cm101730f)
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