Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
Hydrophobicity predicts in vivo 19F magnetic resonance detectability of fluorinated psychiatric drugs: Simple test for likely success in clinical pharmacokinetic studies
– Drug Development Research
(2008)
69,
279
(doi: 10.1002/ddr.20254)
Mineral Surface in Calcified Plaque Is Like That of Bone Further Evidence for Regulated Mineralization
– Arteriosclerosis, thrombosis, and vascular biology
(2008)
28,
2030
(doi: 10.1161/atvbaha.108.172387)
Correlating sideband patterns with powder patterns for accurate determination of chemical shift parameters in solid-state NMR
– Magn Reson Chem
(2008)
46,
913
(doi: 10.1002/mrc.2262)
The organic-mineral interface in teeth is like that in bone and dominated by polysaccharides: Universal mediators of normal calcium phosphate biomineralization in vertebrates?
– Chemistry of Materials
(2008)
20,
3549
(doi: 10.1021/cm800514u)
NMR spectroscopy - a powerful tool in quality control of biosynthetic mineralized composite materials
– TISSUE ENGINEERING PART A
(2008)
14,
887
Fluorine magnetic resonance in vivo: A powerful tool in the study of drug distribution and metabolism
– Drug discovery today
(2008)
13,
473
(doi: 10.1016/j.drudis.2007.12.011)
Towards a model of the mineral–organic interface in bone: NMR of the structure of synthetic glycosaminoglycan‐ and polyaspartate‐calcium phosphate composites
– Magnetic Resonance in Chemistry
(2008)
46,
323
(doi: 10.1002/mrc.2168)
Exploring the relationship between cocrystal stability and symmetry:: is Wallach's rule applicable to multi-component solids?
– Chemical Communications
(2008)
1644
(doi: 10.1039/b717532a)
The organic-mineral interface in bone is predominantly polysaccharide
– Chemistry of Materials
(2007)
19,
5055
(doi: 10.1021/cm702054c)
Automatic quantification of changes in bone in serial MR images of joints.
– IEEE Trans Med Imaging
(2006)
25,
1617
(doi: 10.1109/TMI.2006.884216)
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