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Professor David Spring

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


C-H activation: Complex peptides made simple.
S Bartlett, DR Spring
– Nature chemistry
Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489
SM Geddis, L Carro, JT Hodgkinson, DR Spring
– European Journal of Organic Chemistry
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angew Chem Int Ed Engl
Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.
TH Sum, TJ Sum, WRJD Galloway, S Collins, DG Twigg, F Hollfelder, DR Spring
– Molecules
Partially Saturated Bicyclic Heteroaromatics as an sp(3)-Enriched Fragment Collection
DG Twigg, N Kondo, SL Mitchell, WRJD Galloway, HF Sore, A Madin, DR Spring
– Angew Chem Int Ed Engl
A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles.
F Nie, DL Kunciw, D Wilcke, JE Stokes, WRJD Galloway, S Bartlett, HF Sore, DR Spring
– Angew Chem Int Ed Engl
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
B Morkunas, B Gal, WRJD Galloway, JT Hodgkinson, BM Ibbeson, YS Tan, M Welch, DR Spring
– Beilstein journal of organic chemistry
The reductive cleavage of picolinic amides
DH O'Donovan, C De Fusco, DR Spring
– Tetrahedron Letters
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
– J Struct Biol
Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu
TJ Sum, TH Sum, WRJD Galloway, DR Spring
– Synlett
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address