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Professor David Spring

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.
DG Twigg, N Kondo, SL Mitchell, WRJD Galloway, HF Sore, A Madin, DR Spring
– Angew Chem Int Ed Engl
A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles.
F Nie, DL Kunciw, D Wilcke, JE Stokes, WRJD Galloway, S Bartlett, HF Sore, DR Spring
– Angew Chem Int Ed Engl
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
B Morkunas, B Gal, WRJD Galloway, JT Hodgkinson, BM Ibbeson, YS Tan, M Welch, DR Spring
– Beilstein journal of organic chemistry
The reductive cleavage of picolinic amides
DH O'Donovan, C De Fusco, DR Spring
– Tetrahedron Letters
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
– J Struct Biol
Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu
TJ Sum, TH Sum, WRJD Galloway, DR Spring
– Synlett
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling
Y Wu, LB Olsen, YH Lau, CH Jensen, M Rossmann, YR Baker, HF Sore, S Collins, DR Spring
– Chembiochem
Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
S Collins, S Bartlett, F Nie, HF Sore, DR Spring
– Synthesis (Germany)
A new Pseudomonas quinolone signal (PQS) binding partner: MexG
JT Hodgkinson, J Gross, YR Baker, DR Spring, M Welch
– Chem. Sci.
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, JE Stokes, YS Tan, EG Almeida, B Hardwick, AJ Narvaez, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific reports
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address