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Professor David Spring

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

• Diversity-Oriented Synthesis
• Synthetic Methodology: Medium Ring Synthesis and Natural Product Synthesis
Quorum Sensing
• New Antibiotic Discovery
• Modulation of Protein-Protein Interactions
• Molecular Therapeutics: Chemistry-Driven Drug Discovery

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu
TJ Sum, TH Sum, WRJD Galloway, DR Spring – Synlett (2016)
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling
Y Wu, LB Olsen, YH Lau, CH Jensen, M Rossmann, YR Baker, HF Sore, S Collins, DR Spring – Chembiochem (2016) 17, 689
Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
S Collins, S Bartlett, F Nie, HF Sore, DR Spring – Synthesis (Germany) (2016)
A new Pseudomonas quinolone signal (PQS) binding partner: MexG
JT Hodgkinson, J Gross, YR Baker, DR Spring, M Welch – Chemical Science (2016) 7, 2553
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
A Chattopadhyay, CJ O'Connor, F Zhang, C Galvagnion, WR Galloway, YS Tan, JE Stokes, T Rahman, C Verma, DR Spring, LS Itzhaki – Scientific reports (2016) 6, 23732
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.
TA Alanine, WR Galloway, S Bartlett, JJ Ciardiello, TM McGuire, DR Spring – Org Biomol Chem (2015) 14, 1031
Which microbial factors really are important in Pseudomonas aeruginosa infections?
A Crousilles, E Maunders, S Bartlett, C Fan, EF Ukor, Y Abdelhamid, Y Baker, A Floto, DR Spring, M Welch – Future Microbiology (2015) 10, 1825
New Advances in Diversity-Oriented Synthesis
WRJD Galloway, JE Stokes, DR Spring – (2015) 77
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring – Tetrahedron (2015)
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.
YS Tan, DR Spring, C Abell, CS Verma – Journal of Chemical Theory and Computation (2015) 11, 3199
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address