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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
– Angewandte Chemie
(2024)
e202402267
(doi: 10.1002/ange.202402267)
CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
S Day-Riley, RM West, PD Brear, M Hyvönen, DR Spring
– Kinases and Phosphatases
(2024)
2,
110
(doi: 10.3390/kinasesphosphatases2020007)
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
– Angewandte Chemie International Edition
(2024)
e202402267
(doi: 10.1002/anie.202402267)
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins †
JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring
– Chemical communications (Cambridge, England)
(2024)
60,
706
(doi: 10.1039/d3cc05213c)
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chemical Biology
(2024)
5,
49
(doi: 10.1039/d3cb00176h)
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
T Pantelejevs, P Zuazua-Villar, O Koczy, AJ Counsell, SJ Walsh, NS Robertson, DR Spring, JA Downs, M Hyvönen
– Chem Sci
(2023)
14,
13915
(doi: 10.1039/d3sc03331g)
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution.
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chem Biol
(2023)
5,
49
(doi: 10.1039/d3cb00176h)
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction
J Iegre, S Krajcovicova, A Gunnarsson, L Wissler, H Käck, A Luchniak, S Tångefjord, F Narjes, DR Spring
– Chemical Science
(2023)
14,
10800
(doi: 10.1039/d3sc04083f)
Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
TA King, SJ Walsh, M Kapun, T Wharton, S Krajcovicova, MS Glossop, DR Spring
– Chem Commun (Camb)
(2023)
59,
9868
(doi: 10.1039/d3cc02980h)
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
– Angewandte Chemie (International ed. in English)
(2023)
62,
e202307782
(doi: 10.1002/anie.202307782)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge