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Professor David Spring

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

• Diversity-Oriented Synthesis
• Synthetic Methodology: Medium Ring Synthesis and Natural Product Synthesis
Quorum Sensing
• New Antibiotic Discovery
• Modulation of Protein-Protein Interactions
• Molecular Therapeutics: Chemistry-Driven Drug Discovery

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions
YS Tan, DR Spring, C Abell, CS Verma – Journal of Chemical Theory and Computation (2015) 11, 3199
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.
L Laraia, G McKenzie, DR Spring, AR Venkitaraman, DJ Huggins – Chemistry & Biology (2015) 22, 689
Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction
RJ Scanes, O Grossmann, A Grossmann, DR Spring – Organic Letters (2015) 17, 2462
A two-component 'double-click' approach to peptide stapling
YH Lau, Y Wu, P de Andrade, WR Galloway, DR Spring – Nature protocols (2015) 10, 585
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
A Isidro-Llobet, K Hadje Georgiou, WR Galloway, E Giacomini, MR Hansen, G Méndez-Abt, YS Tan, L Carro, HF Sore, DR Spring – Org Biomol Chem (2015) 13, 4570
Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
TH Sum, TJ Sum, JE Stokes, WRJD Galloway, DR Spring, DR Spring – Tetrahedron (2015) 71, 4557
Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
TH Sum, TJ Sum, JE Stokes, WRJD Galloway, DR Spring – Tetrahedron (2015) 71, 4557
Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction
E Alza, L Laraia, L Laraia, BM Ibbeson, S Collins, WRJD Galloway, JE Stokes, JE Stokes, AR Venkitaraman, DR Spring – Chem. Sci. (2015) 6, 390
Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.
MS Frei, MK Bilyard, TA Alanine, WR Galloway, JE Stokes, DR Spring – Bioorganic & medicinal chemistry (2014) 23, 2666
Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation
Z Walsh, ER Janeček, JT Hodgkinson, J Sedlmair, A Koutsioubas, DR Spring, M Welch, CJ Hirschmugl, C Toprakcioglu, JR Nitschke, M Jones, OA Scherman – Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 17743
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address