Brain showing hallmarks of Alzheimer’s disease (plaques in blue) Credit: NIH Image Gallery
Researchers in the Vendruscolo Group have designed antibodies that target the protein deposits in the brain associated with Alzheimer’s disease, and stop their production.
The results of the group's research are reported in the journal Science Advances. Professor Michele Vendruscolo said: "If we can find better and cheaper ways of producing antibodies, we would increase the chances of finding treatments for patients."
The researchers used computer-based methods to develop antibodies to target the deposits of misfolded proteins which are a hallmark of Alzheimer’s disease. Early tests of the antibodies in test tubes and in nematode worms showed an almost complete elimination of these pathogens.
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Reference:
Francesco A. Aprile et al. ‘Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.’ Science Advances (2017). DOI: 10.1126/sciadv.1700488