Professor Rosana Collepardo-Guevara

University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.

Professor Collepardo discusses her research

Publications

Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions

SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara

– Nat Commun

(2021)

12,

2883

(doi: 10.1038/s41467-021-23090-3)

Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients

I Sanchez-Burgos, J Joseph, R Collepardo-Guevara, J Espinosa

(2021)

2021.04.30.442154

(doi: 10.1101/2021.04.30.442154)

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles

– Nat Commun

(2021)

12,

1085

(doi: 10.1038/s41467-021-21181-9)

Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components

I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara

– Biomolecules

(2021)

11,

278

(doi: 10.3390/biom11020278)