Professor Rosana Collepardo-Guevara

University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.

Professor Collepardo discusses her research

Publications

Study on stability, composition, and protein arrangement within bio-condensates formed via liquid-liquid phase separation

IS Burgos, JR Espinosa, A Garaizar, R Collepardo-Guevara, JA Joseph

– BIOPHYSICAL JOURNAL

(2022)

121,

357A

(link to publication)

Deoxyribonucleic Acid Encoded and Size-Defined π‑Stacking of Perylene Diimides

J Gorman, SRE Orsborne, A Sridhar, R Pandya, P Budden, A Ohmann, NA Panjwani, Y Liu, JL Greenfield, S Dowland, V Gray, STJ Ryan, S De Ornellas, AH El-Sagheer, T Brown, JR Nitschke, J Behrends, UF Keyser, A Rao, R Collepardo-Guevara, E Stulz, RH Friend, F Auras

– Journal of the American Chemical Society

(2021)

144,

368

(doi: 10.1021/jacs.1c10241)

Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy.

J Joseph, A Reinhardt, A Aguirre, PY Chew, K Russell, J Rene Espinosa, A Garaizar, R Collepardo Guevara

– Nature computational science

(2021)

732

(doi: 10.1038/s43588-021-00155-3)

Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?

G da Rosa, L Grille, V Calzada, K Ahmad, JP Arcon, F Battistini, G Bayarri, T Bishop, P Carloni, T Cheatham Iii, R Collepardo-Guevara, J Czub, JR Espinosa, R Galindo-Murillo, SA Harris, A Hospital, C Laughton, JH Maddocks, A Noy, M Orozco, M Pasi, A Pérez, D Petkevičiūtė-Gerlach, R Sharma, R Sun, PD Dans

– Biophysical Reviews

(2021)

13,

995

(doi: 10.1007/s12551-021-00893-8)

The chromatin regulator HMGA1a undergoes phase separation in the nucleus

H Zhu, M Narita, J Joseph, G Krainer, W Arter, I Olan, K Saar, N Ermann, J Espinosa, Y Shen, MA Kuri, R Qi, T Welsh, Y Xu, R Collepardo-Guevara, M Narita, T Knowles

(2021)

2021.10.14.464384

(doi: 10.1101/2021.10.14.464384)

Can single-component protein condensates form multiphase architectures?

A Garaizar, J Espinosa, J Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara

(2021)

(doi: 10.1101/2021.10.09.463670)

Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates

A Garaizar, J Espinosa, J Joseph, R Collepardo-Guevara

(2021)

(doi: 10.1101/2021.10.07.463530)

RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins