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Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 961 publications
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
– Immunity
(2024)
57,
256
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
– Commun Biol
(2024)
7,
153
Selenium-silk microgels as antifungal and antibacterial agents
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
– Nanoscale Horizons
(2024)
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
O Morris, Z Toprakcioglu, A Röntgen, M Cali, T Knowles, M Vendruscolo
(2023)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, S Ruggeri, T Knowles, M Vendruscolo
(2023)
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
B Fu, EE Brock, R Andrews, JC Breiter, R Tian, CE Toomey, J Lachica, T Lashley, M Ryten, NW Wood, M Vendruscolo, S Gandhi, LE Weiss, JS Beckwith, SF Lee
(2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature Structural and Molecular Biology
(2023)
31,
390
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
E Fertan, D Böken, A Murray, JSH Danial, JYL Lam, Y Wu, PA Goh, I Alić, MR Cheetham, E Lobanova, YP Zhang, D Nižetić, D Klenerman
– Mol Psychiatry
(2023)
1
Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides
T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, K Katsuya-Gaviria, MLLY Johncock, G Krainer, A Borodavka, TPJ Knowles
– Nat Commun
(2023)
14,
7170
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
A Dear, X Teng, S Ball, J Lewin, R Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, T Knowles, X Yang, S Brewerton, J Thomson, J Habchi, G Meisl
(2023)
Imaging Protein Aggregates in Parkinson's Disease Serum Using Aptamer-Assisted Single-Molecule Pull-Down.
YP Zhang, E Lobanova, D Emin, SV Lobanov, A Kouli, CH Williams-Gray, D Klenerman
– Analytical Chemistry
(2023)
95,
15254
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature Structural & Molecular Biology
(2023)
30,
1628
Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
– Nat Protoc
(2023)
18,
3975
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
M Vendruscolo, S Dada, Z Toprakcioglu, M Hardenberg, M Cali, L Mrugalla, O Morris, A Roentgen, T Knowles
(2023)
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
(2023)
Ganglioside Lipids Inhibit the Aggregation of the Alzheimer’s Related Peptide Amyloid-β
Z Toprakcioglu, A Jayaram, T Knowles
(2023)
Effects of Processing-Induced Contamination on Organic Electronic Devices.
D Simatos, IE Jacobs, I Dobryden, M Nguyen, A Savva, D Venkateshvaran, M Nikolka, J Charmet, LJ Spalek, M Gicevičius, Y Zhang, G Schweicher, DJ Howe, S Ursel, J Armitage, IB Dimov, U Kraft, W Zhang, M Alsufyani, I McCulloch, RM Owens, PM Claesson, TPJ Knowles, H Sirringhaus
– Small methods
(2023)
7,
e2300476
Thermodynamic profiles for co-translational trigger factor function
T Herling, A Cassaignau, A Wentink, Q Peter, P Kumar, T Kartanas, M Schneider, L Cabrita, J Christodoulou, T Knowles
(2023)
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
(2023)