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  • Currently displaying 1 - 20 of 1052 publications
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
– Nature Chemical Biology
(2025)
1
(doi: 10.1038/s41589-024-01811-1)
Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical chemistry
(2024)
97,
290
(doi: 10.1021/acs.analchem.4c04188)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TPJ Knowles, J Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
– ACS chemical neuroscience
(2024)
16,
40
(doi: 10.1021/acschemneuro.4c00684)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases.
D Böken, Y Wu, Z Zhang, D Klenerman
– ChemBioChem
(2024)
e202400877
(doi: 10.1002/cbic.202400877)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
– Brain communications
(2024)
7,
fcae454
(doi: 10.1093/braincomms/fcae454)
Detecting and Tracking β‑Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
– ACS Chemical Neuroscience
(2024)
15,
4383
(doi: 10.1021/acschemneuro.4c00312)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
– Chemical science
(2024)
16,
670
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
– Nature Communications
(2024)
15,
10038
(doi: 10.1038/s41467-024-54212-2)
Dynamically arrested condensate fusion creates complex structures with varying material properties
N Erkamp, I Sanchez-Burgos, A Zhou, T Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, D Weitz, J Espinosa, T Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
E Lobanova, YP Zhang, D Emin, J Brelstaff, L Kahanawita, M Malpetti, A Quaegebeur, K Triantafilou, M Triantafilou, H Zetterberg, JB Rowe, CH Williams-Gray, CE Bryant, D Klenerman
– Nat Commun
(2024)
15,
9690
(doi: 10.1038/s41467-024-53547-0)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
E Lobanova, YP Zhang, D Emin, J Brelstaff, L Kahanawita, M Malpetti, A Quaegebeur, K Triantafilou, M Triantafilou, H Zetterberg, JB Rowe, CH Williams-Gray, CE Bryant, D Klenerman
– Nature Communications
(2024)
15,
9690
(doi: 10.1038/s41467-024-53547-0)
Global kinetic model of lipid-inducedα-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, A Dear, D Voderholzer, G Meisl, R Guido, C Galvagnion, A Buell, TPJ Knowles, M Vendruscolo, TCT Michaels
(2024)
(doi: 10.1101/2024.11.07.622437)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
D Klenerman, E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper
(2024)
(doi: 10.21203/rs.3.rs-5290983/v1)
Vortex Light Field Microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, LM Needham, R Peters, SF Lee, K O’Holleran
– Optica
(2024)
11,
1519
(doi: 10.1364/optica.534148)
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, S Grant, M Horrocks, S Lee
(2024)
(doi: 10.1101/2024.10.14.617231)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper, D Klenerman
(2024)
(doi: 10.1101/2024.10.11.617910)
POLCAM: instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nature Methods
(2024)
21,
1873
(doi: 10.1038/s41592-024-02382-8)
Biomolecular Condensates are Characterized by Interphase Electric Potentials
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
– Journal of the American Chemical Society
(2024)
146,
28268
(doi: 10.1021/jacs.4c08946)

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