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  • Currently displaying 41 - 60 of 1086 publications
Assessment of fine-tuned large language models for real-world chemistry and material science applications
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
– Chemical science
(2024)
16,
670
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway.
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
– Nature Communications
(2024)
15,
10038
(doi: 10.1038/s41467-024-54212-2)
Dynamically arrested condensate fusion creates complex structures with varying material properties
N Erkamp, I Sanchez-Burgos, A Zhou, T Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, D Weitz, J Espinosa, T Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
D Klenerman
– Nature Communications
(2024)
15,
9690
(doi: 10.1038/s41467-024-53547-0)
Global kinetic model of lipid-inducedα-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, A Dear, D Voderholzer, G Meisl, R Guido, C Galvagnion, A Buell, TPJ Knowles, M Vendruscolo, TCT Michaels
(2024)
(doi: 10.1101/2024.11.07.622437)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
D Klenerman, E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper
(2024)
(doi: 10.21203/rs.3.rs-5290983/v1)
Oxidation-sensitive cysteines drive IL-38 amyloid formation.
A Diaz-Barreiro, G Cereghetti, FG Ortega Sánchez, J Tonacini, D Talabot-Ayer, S Kieffer-Jaquinod, VM Kissling, A Huard, C Swale, TPJ Knowles, Y Couté, M Peter, A Francés-Monerris, G Palmer
– Cell Rep
(2024)
43,
114940
(doi: 10.1016/j.celrep.2024.114940)
Vortex Light Field Microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, LM Needham, R Peters, SF Lee, K O’Holleran
– Optica
(2024)
11,
1519
(doi: 10.1364/optica.534148)
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, S Grant, M Horrocks, S Lee
(2024)
(doi: 10.1101/2024.10.14.617231)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper, D Klenerman
(2024)
(doi: 10.1101/2024.10.11.617910)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nat Methods
(2024)
21,
1873
(doi: 10.1038/s41592-024-02382-8)
Biomolecular Condensates are Characterized by Interphase Electric Potentials
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
– J Am Chem Soc
(2024)
146,
28268
(doi: 10.1021/jacs.4c08946)
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
– Scientific reports
(2024)
14,
22633
(doi: 10.1038/s41598-024-72265-7)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping.
K Nakajima, T Sneideris, LL Good, NA Erkamp, H Ogi, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.16.613217)
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
– Nature communications
(2024)
15,
7740
(doi: 10.1038/s41467-024-50825-9)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
Unraveling the Structure and Dynamics of Ac-PHF6-NH2 Tau Segment Oligomers
I Stroganova, Z Toprakcioglu, H Willenberg, TPJ Knowles, AM Rijs
– ACS chemical neuroscience
(2024)
15,
3391
(doi: 10.1021/acschemneuro.4c00404)
Surface effects on functional amyloid formation
AJ Dear, G Meisl, CG Taylor, UC Palmiero, SN Stubbe, Q Liu, P Arosio, S Linse, TPJ Knowles, M Andreasen
– Nanoscale
(2024)
16,
16172
(doi: 10.1039/d4nr01496k)
Aggregate-selective removal of pathological tau by clustering-activated degraders
J Benn, S Cheng, S Keeling, AE Smith, MJ Vaysburd, D Böken, LVC Miller, T Katsinelos, C Franco, E Dupré, C Danis, I Landrieu, L Buée, D Klenerman, LC James, WA McEwan
– Science (New York, N.Y.)
(2024)
385,
1009
(doi: 10.1126/science.adp5186)
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
(2024)
(doi: 10.1101/2024.08.24.609517)

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