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  • Currently displaying 21 - 40 of 1086 publications
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
– Biophysical Journal
(2025)
124,
79a
(doi: 10.1016/j.bpj.2024.11.489)
BPS2025 - Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
– Biophysical Journal
(2025)
124,
79a
(doi: 10.1016/j.bpj.2024.11.488)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
– Biophysical Journal
(2025)
124,
29a
(doi: 10.1016/j.bpj.2024.11.217)
BPS2025 - Sequence-encoded molecular grammar governs the formation of synaptic condensates
C Hoffmann, K Ruff, IA Edu, MK Shinn, JV Tromm, A Pant, H Ausserwöger, J Morgan, TP Knowles, RV Pappu, D Milovanovic
– Biophysical Journal
(2025)
124,
562a
(doi: 10.1016/j.bpj.2024.11.2925)
BPS2025 - Single-molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteins
M Sahu, J Wei, VK V, TP Knowles, K Garai
– Biophysical Journal
(2025)
124,
411a
(doi: 10.1016/j.bpj.2024.11.2208)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
G Meisl, S-H Huang, A Quaegebeur, T Rittman, M Cotton, J Rowe, TP Knowles, D Klenerman
– Biophysical Journal
(2025)
124,
408a
(doi: 10.1016/j.bpj.2024.11.2197)
BPS2025 - Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
– Biophysical Journal
(2025)
124,
78a
(doi: 10.1016/j.bpj.2024.11.486)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
– Biophysics Reviews
(2025)
6,
011303
(doi: 10.1063/5.0236947)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation.
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2401307122
(doi: 10.1073/pnas.2401307122)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
– Cell Chem Biol
(2025)
32,
338
(doi: 10.1016/j.chembiol.2025.01.001)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
– Nat Chem Biol
(2025)
1
(doi: 10.1038/s41589-024-01811-1)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
– Chembiochem : a European journal of chemical biology
(2025)
26,
e202400877
(doi: 10.1002/cbic.202400877)
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
– Sustainable Food Technology
(2025)
(doi: 10.1039/d4fb00375f)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
– Mol Cell
(2024)
85,
585
(doi: 10.1016/j.molcel.2024.11.039)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform.
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical Chemistry
(2024)
97,
290
(doi: 10.1021/acs.analchem.4c04188)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TPJ Knowles, J Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
– ACS Chemical Neuroscience
(2024)
16,
40
(doi: 10.1021/acschemneuro.4c00684)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
– Brain Communications
(2024)
7,
fcae454
(doi: 10.1093/braincomms/fcae454)
Detecting and Tracking β‑Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
– ACS Chemical Neuroscience
(2024)
15,
4383
(doi: 10.1021/acschemneuro.4c00312)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)

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