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  • Currently displaying 101 - 120 of 1085 publications
Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
– Cancer Research
(2024)
84,
4891
(doi: 10.1158/1538-7445.am2024-4891)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
– Cancer Research
(2024)
84,
1657
(doi: 10.1158/1538-7445.am2024-1657)
Design of amyloidogenic peptide traps.
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
– Nature chemical biology
(2024)
20,
981
(doi: 10.1038/s41589-024-01578-5)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics.
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
– Biofabrication
(2024)
16,
025023
(doi: 10.1088/1758-5090/ad2b05)
High-density volumetric super-resolution microscopy.
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
– Nature Communications
(2024)
15,
1940
(doi: 10.1038/s41467-024-45828-5)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
– Nature Communications
(2024)
15,
1940
(doi: 10.1038/s41467-024-45828-5)
A Relationship Between Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
– ACS Chem Neurosci
(2024)
15,
1125
(doi: 10.1021/acschemneuro.3c00718)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, C Toomey, J Breiter, J Lachica, R Tian, J Beckwith, L-M Needham, G Chant, C Loiseau, A Deconfin, K Baspin, P Magill, Z Jaunmuktane, O Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, N Wood, L Weiss, S Gandhi, S Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
– Immunity
(2024)
57,
256
(doi: 10.1016/j.immuni.2024.01.007)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin–Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
– Bioconjugate Chemistry
(2024)
35,
132
(doi: 10.1021/acs.bioconjchem.3c00478)
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
e2220075121
(doi: 10.1073/pnas.2220075121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
– Commun Biol
(2024)
7,
153
(doi: 10.1038/s42003-024-05858-7)
Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
C Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, T Knowles
(2024)
(doi: 10.1101/2024.02.02.578543)
Molecular chaperones and their role in amyloid formation
MM Schneider, A Bracher, EA Andrzejewska, G Krainer, L-U Lin, R Riek, U Hartl, TPJ Knowles
– Biophysical Journal
(2024)
123,
301a
(doi: 10.1016/j.bpj.2023.11.1869)
Novel methods to study amyloid oligomers
LO Pascual, EA Andrzejewska, T Pálmadóttir, TP Knowles, S Linse
– Biophysical Journal
(2024)
123,
41a
(doi: 10.1016/j.bpj.2023.11.331)
Thermodynamics of temperature modulation in biomolecular phase separation
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
– Biophysical Journal
(2024)
123,
495a
(doi: 10.1016/j.bpj.2023.11.2994)
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
(doi: 10.1101/2024.01.14.575549)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy.
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
– Frontiers in immunology
(2024)
14,
1296148
(doi: 10.3389/fimmu.2023.1296148)
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
O Morris, Z Toprakcioglu, A Röntgen, M Cali, T Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.23.573169)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, S Ruggeri, T Knowles, M Vendruscolo
(2023)
(doi: 10.1101/2023.12.21.572955)

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