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  • Currently displaying 41 - 60 of 252 publications
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination.
L Dunsmore, CD Navo, J Becher, EG de Montes, A Guerreiro, E Hoyt, L Brown, V Zelenay, S Mikutis, J Cooper, I Barbieri, S Lawrinowitz, E Siouve, E Martin, PR Ruivo, T Rodrigues, FP da Cruz, O Werz, G Vassiliou, P Ravn, G Jiménez-Osés, GJL Bernardes
– Nature Chemistry
(2022)
14,
754
(doi: 10.1038/s41557-022-00964-7)
A Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
A Istrate, MB Geeson, CD Navo, BB Sousa, MC Marques, RJ Taylor, T Journeaux, SR Oehler, MR Mortensen, MJ Deery, AD Bond, F Corzana, G Jiménez-Osés, GJL Bernardes
– J Am Chem Soc
(2022)
144,
10396
(doi: 10.1021/jacs.2c02185)
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.
LAR Carvalho, GJL Bernardes
– ChemMedChem
(2022)
17,
e202200174
(doi: 10.1002/cmdc.202200174)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, G Lopes Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
– Nature Communications
(2022)
13,
(doi: 10.1038/s41467-022-30083-3)
Structural insights into TRPV2 activation by small molecules.
G Lopes Bernardes, R pumroy, A Protopopova, T Fricke, I Lange, F Haug, P Nguyen, P gallo, B sousa, V yarov-yarovoy, A leffler, V moiseenkova-bell
– Nature communications
(2022)
13,
2334
(doi: 10.1038/s41467-022-30083-3)
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo.
TCL Kohs, SR Olson, J Pang, KR Jordan, TJ Zheng, A Xie, J Hodovan, M Muller, C McArthur, J Johnson, BB Sousa, M Wallisch, P Kievit, JE Aslan, JD Seixas, GJL Bernardes, MT Hinds, JR Lindner, OJT McCarty, C Puy, JJ Shatzel
– Cell Mol Bioeng
(2022)
15,
231
(doi: 10.1007/s12195-022-00723-1)
Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
– J Am Chem Soc
(2022)
144,
5284
(doi: 10.1021/jacs.1c07675)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
– Chemical Science
(2022)
(doi: 10.1039/D1SC01928G)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.
F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo
– Chem Sci
(2022)
13,
2440
(doi: 10.1039/d1sc01928g)
Transition metal mediated bioorthogonal release
V Sabatino, VB Unnikrishnan, GJL Bernardes
– Chem Catalysis
(2022)
2,
39
(doi: 10.1016/j.checat.2021.12.007)
Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging
J Konč, V Sabatino, E Jiménez‐Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes
– Angewandte Chemie
(2022)
134,
(doi: 10.1002/ange.202113519)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.
ZF Brotzakis, PR Lindstedt, RJ Taylor, DJ Rinauro, NCT Gallagher, GJL Bernardes, M Vendruscolo
– ACS Cent Sci
(2021)
7,
1986
(doi: 10.1021/acscentsci.1c00585)
A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
– ACS Central Science
(2021)
(doi: 10.21203/rs.3.rs-215084/v1)
Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates**
JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois
– Angew Chem Int Ed Engl
(2021)
60,
25914
(doi: 10.1002/anie.202109835)
Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.
J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes
– Angew Chem Int Ed Engl
(2021)
61,
e202113519
(doi: 10.1002/anie.202113519)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2021)
60,
25905
(doi: 10.1002/anie.202109713)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
– Angewandte Chemie
(2021)
133,
26109
(doi: 10.1002/ange.202109713)
Bioorthogonal Self-lmmolative Linker Based on Grob Fragmentation
X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana
– Org Lett
(2021)
23,
8580
(doi: 10.1021/acs.orglett.1c03299)
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems.
TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes
– J Am Chem Soc
(2021)
143,
16401
(doi: 10.1021/jacs.1c03681)
Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent
V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes
– Angewandte Chemie
(2021)
133,
23943
(doi: 10.1002/ange.202108791)

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