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  • Currently displaying 21 - 40 of 252 publications
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes
– Angewandte Chemie
(2023)
135,
(doi: 10.1002/ange.202311186)
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
– Angew Chem Int Ed Engl
(2023)
62,
e202311186
(doi: 10.1002/anie.202311186)
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJD Gonzalez, NR Bennett, P Venkatesh, D Satoe, M Ahlrichs, C Dobbins, W Yang, X Wang, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, GJL Bernardes, KT Roybal, P Greisen, X Li, C Bertozzi, D Baker
– bioRxiv
(2023)
4,
2023.08.19.553321
(doi: 10.1101/2023.08.19.553321)
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
S Sandler, R Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, F Brotzakis, R Gregory, S Chia, G Bernardes, U Keyser, M Vendruscolo
(2023)
(doi: 10.1101/2023.08.09.552642)
Targeted protein modification with an antibody-based system
O Rimon, J Konc, M Ali, V Roy Chowdhury, I Černauskienė, P Sormanni, G Bernardes, M Vendruscolo
(2023)
(doi: 10.1101/2023.07.28.551006)
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
– J Infect Dis
(2023)
228,
723
(doi: 10.1093/infdis/jiad135)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie
(2023)
135,
(doi: 10.1002/ange.202304449)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angew Chem Int Ed Engl
(2023)
62,
e202304449
(doi: 10.1002/anie.202304449)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
– Journal of the American Chemical Society
(2023)
145,
10790
(doi: 10.1021/jacs.3c01960)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
– ACS Cent Sci
(2023)
9,
892
(doi: 10.1021/acscentsci.3c00015)
Introducing the 2023 Bioconjugate Chemistry Editorial Team
GJL Bernardes, P Zou, Z Dai, E Lavik, J van Hest, G Zheng, N Quinn, CM MacLaughlin, TM Reineke
– Bioconjugate Chemistry
(2023)
34,
279
(doi: 10.1021/acs.bioconjchem.3c00033)
SnapShot: Clinical and preclinical utility of click chemistry.
S Mikutis, GJL Bernardes
– Cell
(2023)
186,
662
(doi: 10.1016/j.cell.2023.01.018)
Strategies for Conditional Regulation of Proteins
K Nadendla, GG Simpson, J Becher, T Journeaux, M Cabeza-Cabrerizo, GJL Bernardes
– JACS Au
(2023)
3,
344
(doi: 10.1021/jacsau.2c00654)
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
C Tang, AR Coelho, M Rebelo, H Kiely-Collins, T Carvalho, GJL Bernardes
– ACS central science
(2023)
9,
109
(doi: 10.1021/acscentsci.2c01243)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
– Angewandte Chemie
(2022)
134,
(doi: 10.1002/ange.202208543)
Fragment-based computational design of antibodies targeting structured epitopes
M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
– Sci Adv
(2022)
8,
eabp9540
(doi: 10.1126/sciadv.abp9540)
Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes
– ACS pharmacology & translational science
(2022)
5,
1156
(doi: 10.1021/acsptsci.2c00163)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
– Angew Chem Int Ed Engl
(2022)
61,
e202208543
(doi: 10.1002/anie.202208543)
Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation
RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes
– Journal of the American Chemical Society
(2022)
144,
14404
(doi: 10.1021/jacs.2c00129)
p-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
RJ Taylor, M Aguilar Rangel, MB Geeson, P Sormanni, M Vendruscolo, GJL Bernardes
– Journal of the American Chemical Society
(2022)
144,
13026
(doi: 10.1021/jacs.2c04747)

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