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  • Currently displaying 1 - 20 of 252 publications
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
– JACS Au
(2025)
5,
2309
(doi: 10.1021/jacsau.5c00249)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
G Lopes Bernardes, B Gless, E Jones
– Angewandte Chemie International Edition
(2025)
137,
(doi: 10.1002/ange.202502268)
Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
V Sabatino, S Fleisch, C Tang, FM Müller, C Labão-Almeida, WT Khaw, S Hogan, DR Hicks, M Fontes, AR Coelho, W Yang, I Sarkar, D Shome, AV Vidal, M Cabeza-Cabrerizo, T Rohm, RM Reijmers, D Kaymak, F Gerster, D Baker, R Fior, G Hutter, GJL Bernardes
(2025)
(doi: 10.1101/2025.03.13.642658)
Correction to “Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform”
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical chemistry
(2025)
97,
4251
(doi: 10.1021/acs.analchem.5c00703)
Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Anal Chem
(2024)
97,
290
(doi: 10.1021/acs.analchem.4c04188)
Site-specific Quadruple-Functionalised Antibodies
T Journeaux, MB Geeson, TV Murray, MA Papworth, M Gothard, JG Kettle, AV Vasco, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2024)
64,
e202417620
(doi: 10.1002/anie.202417620)
Technologies for targeted RNA degradation and induced RNA decay
S Mikutis, GJL Bernardes
– Chem Rev
(2024)
124,
13301
(doi: 10.1021/acs.chemrev.4c00472)
Non-Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
A Guerreiro, I Compañón, FS Lazaris, C Labão-Almeida, P Oroz, M Ghirardello, MC Marques, F Corzana, GJL Bernardes
– Angewandte Chemie International Edition
(2024)
63,
e202411009
(doi: 10.1002/anie.202411009)
Small Molecule RNA Degraders
J Bonet-Aleta, T Maehara, BA Craig, GJL Bernardes
– Angew Chem Int Ed Engl
(2024)
63,
e202412925
(doi: 10.1002/anie.202412925)
Designed endocytosis-inducing proteins degrade targets and amplify signals.
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, C Tang, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, L Yi, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJ Duran Gonzalez, NR Bennett, P Venkatesh, M Ahlrichs, C Dobbins, W Yang, X Wang, DD Sahtoe, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, KT Roybal, PJ Greisen, X Li, GJL Bernardes, CR Bertozzi, D Baker
– Nature
(2024)
638,
1
(doi: 10.1038/s41586-024-07948-2)
Proximity-driven site-specific cyclization of phage-displayed peptides.
L Brown, AV Vidal, AL Dias, T Rodrigues, A Sigurdardottir, T Journeaux, S O'Brien, TV Murray, P Ravn, M Papworth, GJL Bernardes
– Nature Communications
(2024)
15,
7308
(doi: 10.1038/s41467-024-51610-4)
Gold (III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-acid Mediated Allyl Substitution
VB Unnikrishnan, V Sabatino, F Amorim, MF Estrada, CD Navo, G Jimenez-Oses, R Fior, GJL Bernardes
– Journal of the American Chemical Society
(2024)
146,
23240
(doi: 10.1021/jacs.4c05582)
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein-Protein Conjugates
AV Vasco, RJ Taylor, Y Méndez, GJL Bernardes
– Journal of the American Chemical Society
(2024)
146,
20709
(doi: 10.1021/jacs.4c03721)
Homogeneous multi-payload antibody-drug conjugates.
T Journeaux, GJL Bernardes
– Nat Chem
(2024)
16,
854
(doi: 10.1038/s41557-024-01507-y)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
(doi: 10.21203/rs.3.rs-3947849/v1)
Cathepsin B Processing is Required for the in vivo Efficacy of Albumin-Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
– Bioconjugate chemistry
(2024)
35,
132
(doi: 10.1021/acs.bioconjchem.3c00478)
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1
G Lopes Bernardes
– ChemBioChem
(2024)
25,
e202300736
(doi: 10.1002/cbic.202300736)
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms.
S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes
– ACS Chemical Biology
(2023)
19,
217
(doi: 10.1021/acschembio.3c00725)
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses.
IA Bermejo, A Guerreiro, A Eguskiza, N Martínez-Sáez, FS Lazaris, A Asín, VJ Somovilla, I Compañón, TK Raju, S Tadic, P Garrido, J García-Sanmartín, V Mangini, AS Grosso, F Marcelo, A Avenoza, JH Busto, F García-Martín, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, A Martínez, R Fiammengo, F Corzana
– JACS Au
(2023)
4,
150
(doi: 10.1021/jacsau.3c00587)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
– J Am Chem Soc
(2023)
145,
25776
(doi: 10.1021/jacs.3c09335)

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