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  • Currently displaying 61 - 80 of 252 publications
Combating small-molecule aggregation with machine learning
K Lee, A Yang, YC Lin, D Reker, GJL Bernardes, T Rodrigues
– Cell Reports Physical Science
(2021)
2,
100573
(doi: 10.1016/j.xcrp.2021.100573)
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory
– Mol Cell
(2021)
81,
3323
(doi: 10.1016/j.molcel.2021.06.031)
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5‑LOX Inhibitor that Limits Inflammation
K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle
– Journal of medicinal chemistry
(2021)
64,
11496
(doi: 10.1021/acs.jmedchem.1c00806)
Arylethynyltrifluoroborate Dienophiles for On Demand Activation of IEDDA Reactions
Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes
– Bioconjug Chem
(2021)
32,
1812
(doi: 10.1021/acs.bioconjchem.1c00276)
Protein Conjugation by Electrophilic Alkynylation using 5-(Alkynyl) dibenzothiophenium Triflates
V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes
– Bioconjugate Chemistry
(2021)
32,
1570
(doi: 10.1021/acs.bioconjchem.1c00317)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
– ACS central science
(2021)
7,
868
(doi: 10.1021/acscentsci.1c00070)
The role of reversible and irreversible covalent chemistry in targeted protein degradation
H Kiely-Collins, GE Winter, GJL Bernardes
– Cell chemical biology
(2021)
28,
952
(doi: 10.1016/j.chembiol.2021.03.005)
Precise protein conjugation technology for the construction of homogenous glycovaccines
A Kitowski, F Corzana, GJL Bernardes
– Drug Discovery Today: Technologies
(2021)
38,
69
(doi: 10.1016/j.ddtec.2020.11.007)
Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis
PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo
– ACS Chemical Neuroscience
(2021)
12,
557
(doi: 10.1021/acschemneuro.0c00761)
TRPV2 Modulation by Small Molecules and Lipids
AD Protopopova, RA Pumroy, J de la Roche, FM Haug, BB Sousa, PN Gallo, GJL Bernardes, A Leffler, VY Moiseenkova-Bell
– BIOPHYSICAL JOURNAL
(2021)
120,
112A
(link to publication)
Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 16, pg 3586, 2020)
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, TPJ Knowles
– Soft matter
(2020)
17,
201
(doi: 10.1039/d0sm90246b)
In Vivo Pretargeting Based on Cysteine-selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
– Bioconjug Chem
(2020)
32,
121
(doi: 10.1021/acs.bioconjchem.0c00551)
Systematic Activity Maturation of a Single-Domain Antibody with Non-Canonical Amino Acids through Chemical Mutagenesis
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
– Cell chemical biology
(2020)
28,
70
(doi: 10.1016/j.chembiol.2020.11.002)
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
G Lopes Bernardes
– Cell Reports Physical Science
(2020)
(doi: 10.1016/j.xcrp.2020.100247)
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
D Reker, EA Hoyt, GJL Bernardes, T Rodrigues
– Cell Reports Physical Science
(2020)
1,
100247
(doi: 10.1016/j.xcrp.2020.100247)
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana
– Chemical communications (Cambridge, England)
(2020)
56,
15137
(doi: 10.1039/d0cc06349e)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
– biorxiv
(2020)
2020.11.10.376285
(doi: 10.1101/2020.11.10.376285)
Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide.
P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo
– Proc Natl Acad Sci U S A
(2020)
117,
29795
(doi: 10.1073/pnas.2011385117)
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation
S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, GS Vassiliou, Y Shi, K Tzelepis, GJL Bernardes
– ACS Cent Sci
(2020)
6,
2196
(doi: 10.1021/acscentsci.0c01094)
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions.
E Latocheski, GM Dal Forno, TM Ferreira, BL Oliveira, GJL Bernardes, JB Domingos
– Chem Soc Rev
(2020)
49,
7710
(doi: 10.1039/d0cs00630k)

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