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University Assistant Professor

"Life is nothing but an electron looking for a place to rest"  

- Albert Szent-Györgyi (Nobel Laureate in Physiology 1937)

Current research

My team's goal is to develop smart bio-hybrid approaches that can help to probe or re-wire the bioenergetics of living systems. These can serve as platforms to launch new biotechnologies to address a range of societal needs, including for renewable energy generation, carbon recycling, precision farming, environmental sensing, and treating pathogenic biofilms. Currently, we are focused on understanding and re-wiring photosynthesis towards sustainable energy conversion. We work at the intersection of many disciplines, including physics, synthetic biology, chemical biology, engineering and material science; but at the heart of our work is electrochemistry.

Please see our website for more info: https://www.ch.cam.ac.uk/group/zhang

**PhD positions available. Contact Jenny and attach your CV to enquire.**

Jenny completed her PhD in bioinorganic chemistry at the University of Sydney, Australia, with a brief stint at the Hebrew University of Jerusalem. During this time, she developed redox active platinum-based anti-cancer agents and studied their biodistribtion and metabolism within tumour models. Following this, she was awarded a Marie Curie Incoming International Fellowship at the University of Cambridge to explore how biocatalysts can be exploited to generate solar fuels. In particular, she worked on developing strategies to re-wire complex enzymes, such as the water-oxidation enzyme photosystem II, to electrodes/semiconductors/other proteins in an emerging field known as 'semi-artificial photosynthesis'. She has since been awarded a BBSRC David Phillips Fellowship, followed by appointment to Assistant Professor in Materials Chemistry at the Yusuf Hamied Department of Chemistry. Here, she takes on the re-wiring of photosynthesis to another level of complexity - in living cells! She was awarded the RSC Felix Franks Biotechnology Medal and the L'Oreal UNESCO Sustainable Development award for Women in Science. Most recently, she won the Outstanding Supervisor Award 2024 in her department.

Watch Dr Zhang discuss her research

Publications

The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models
JZ Zhang, NS Bryce, R Siegele, EA Carter, D Paterson, MD de Jonge, DL Howard, CG Ryan, TW Hambley
– Integrative Biology
(2012)
4,
1072
Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES).
MD Hall, HL Daly, JZ Zhang, M Zhang, RA Alderden, D Pursche, GJ Foran, TW Hambley
– Metallomics
(2012)
4,
568
Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate
JZ Zhang, E Wexselblatt, TW Hambley, D Gibson
– Chem Commun (Camb)
(2011)
48,
847
Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells.
EJ New, C Roche, R Madawala, JZ Zhang, TW Hambley
– Journal of Inorganic Biochemistry
(2009)
103,
1120
Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models
NS Bryce, JZ Zhang, RM Whan, N Yamamoto, TW Hambley
– Chem Commun (Camb)
(2009)
8,
2673
Investigations using fluorescent ligands to monitor platinum( iv ) reduction and platinum( ii ) reactions in cancer cells
EJ New, R Duan, JZ Zhang, TW Hambley
– Dalton Trans
(2009)
3092
Platinum Anticancer Drugs, Chemical Biology of
J Zhang, R Whan, T Hambley
(2008)
1
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