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The Clarke Group

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  • Currently displaying 1 - 20 of 163 publications
Adaptation of proteins to the cold in Antarctic fish: A role for methionine?
C Berthelot, J Clarke, T Desvignes, H William Detrich, P Flicek, LS Peck, M Peters, JH Postlethwait, MS Clark
– Genome Biology and Evolution
(2019)
11,
220
The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome
P Tian, A Steward, R Kudva, T Su, PJ Shilling, AA Nickson, JJ Hollins, R Beckmann, G von Heijne, J Clarke, RB Best
– Proceedings of the National Academy of Sciences
(2018)
115,
E11284
Non-Native Cooperative Interactions Modulate Protein Folding Rates
F Bruno da Silva, VG Contessoto, VM de Oliveira, J Clarke, VBP Leite
– Journal of Physical Chemistry B
(2018)
122,
10817
Investigating the Effect of Chain Connectivity on the Folding of a Beta-Sheet Protein On and Off the Ribosome.
AP Marsden, JJ Hollins, C O'Neill, P Ryzhov, S Higson, CATF Mendonça, TO Kwan, LG Kwa, A Steward, J Clarke
– J Mol Biol
(2018)
430,
5207
Promiscuous and selective: how intrinsically disordered BH3- proteins interact with their pro-survival partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
– Journal of Molecular Biology
(2018)
430,
2468
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
MD Crabtree, CATF Mendonça, QR Bubb, J Clarke
– J Biol Chem
(2018)
293,
9718
Erratum: Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (Nature communications (2017) 8 1 (1095))
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nature communications
(2018)
9,
1073
Conservation of Folding Mechanism in Cotranslational Folding of Titin I27
P Tian, A Steward, J Clarke, RB Best
– Biophysical Journal
(2018)
114,
593a
Promiscuous but selective: how intrinsically disordered BH3-only proteins regulate apoptosis through binding to BCL-2 like proteins
L Dahal, J Clarke
– PROTEIN SCIENCE
(2017)
26,
118
Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex.
L Dahal, SL Shammas, J Clarke
– Biophysical journal
(2017)
113,
2706
pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.
L Dahal, TOC Kwan, SL Shammas, J Clarke
– Biophysical Journal
(2017)
113,
2713
Disorder, Evolution and Plasticity: Biophysical Signatures of the Arbitration of Apoptosis
B Wicky, T Kwan, J Clarke
– PROTEIN SCIENCE
(2017)
26,
122
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nature Communications
(2017)
8,
1095
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure
BIM Wicky, SL Shammas, J Clarke
– Proc Natl Acad Sci U S A
(2017)
114,
9882
Mechanistic studies of folding upon binding
J Clarke
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S112
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
MD Crabtree, W Borcherds, A Poosapati, SL Shammas, GW Daughdrill, J Clarke
– Biochemistry
(2017)
56,
2379
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1.
W-T Chu, J Clarke, SL Shammas, J Wang
– PLoS computational biology
(2017)
13,
e1005468
Effect of Transient Helicity of cMyb TAD on its Binding Affinity to the Kix Domain of CBP/p300
A Poosapati, W Borcherds, MD Carbtree, SL Shammas, J Clarke, GW Daughdrill
– FASEB JOURNAL
(2017)
31,
Cotranslational folding of spectrin domains via partially structured states
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
– Nature structural & molecular biology
(2017)
24,
221
What Encodes Coupled Folding and Binding Reactions: IDPS or Partner Proteins?
MD Crabtree, CATF Mendonca, Q Bubb, SL Shammas, J Clarke
– Biophysical Journal
(2017)
112,
481a