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The Clarke Group

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  • Currently displaying 1 - 20 of 160 publications
Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
– Journal of molecular biology
(2018)
430,
2468
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
MD Crabtree, CATF Mendonça, QR Bubb, J Clarke
– J Biol Chem
(2018)
293,
9718
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (vol 8, 2017)
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nature Communications
(2018)
9,
1073
Conservation of Folding Mechanism in Cotranslational Folding of Titin I27
P Tian, A Steward, J Clarke, RB Best
– BIOPHYSICAL JOURNAL
(2018)
114,
593A
pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.
L Dahal, TOC Kwan, SL Shammas, J Clarke
– Biophys J
(2017)
113,
2713
Promiscuous but selective: how intrinsically disordered BH3-only proteins regulate apoptosis through binding to BCL-2 like proteins
L Dahal, J Clarke
– PROTEIN SCIENCE
(2017)
26,
118
Disorder, Evolution and Plasticity: Biophysical Signatures of the Arbitration of Apoptosis
B Wicky, T Kwan, J Clarke
– PROTEIN SCIENCE
(2017)
26,
122
Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex
L Dahal, SL Shammas, J Clarke
– Biophys J
(2017)
113,
2706
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nature Communications
(2017)
8,
1095
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.
BIM Wicky, SL Shammas, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
9882
Mechanistic studies of folding upon binding
J Clarke
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S112
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
MD Crabtree, W Borcherds, A Poosapati, SL Shammas, GW Daughdrill, J Clarke
– Biochemistry
(2017)
56,
2379
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1.
W-T Chu, J Clarke, SL Shammas, J Wang
– PLoS computational biology
(2017)
13,
e1005468
Effect of Transient Helicity of cMyb TAD on its Binding Affinity to the Kix Domain of CBP/p300
A Poosapati, W Borcherds, MD Carbtree, SL Shammas, J Clarke, GW Daughdrill
– FASEB JOURNAL
(2017)
31,
Cotranslational folding of spectrin domains via partially structured states.
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
– Nature Structural & Molecular Biology
(2017)
24,
221
What Encodes Coupled Folding and Binding Reactions: IDPS or Partner Proteins?
MD Crabtree, CATF Mendonca, Q Bubb, SL Shammas, J Clarke
– Biophysical Journal
(2017)
112,
481A
Editorial overview: Protein Folding and Binding, Complexity Comes of Age
J Clarke, RV Pappu
– Current opinion in structural biology
(2017)
42,
v
Disorder drives cooperative folding in a multidomain protein.
DT Gruszka, CATF Mendonça, E Paci, F Whelan, J Hawkhead, JR Potts, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
11841
Protein folding - on and off the ribosome: Using Physics and Chemistry to understand Biology
J Clarke
– PROTEIN SCIENCE
(2016)
25,
175
Cotranslational folding studies of spectrin and Ig-like domains show folding occurs close to the ribosome
A Steward, OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Marsden, C Mendonca, R Beckmann, G von Heijne, J Clarke
– PROTEIN SCIENCE
(2016)
25,
107