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The Clarke Group

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  • Currently displaying 1 - 20 of 151 publications
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nature Communications
(2017)
8,
1095
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.
BIM Wicky, SL Shammas, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
9882
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
MD Crabtree, W Borcherds, A Poosapati, SL Shammas, GW Daughdrill, J Clarke
– Biochemistry
(2017)
56,
2379
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1.
W-T Chu, J Clarke, SL Shammas, J Wang
– PLoS computational biology
(2017)
13,
e1005468
Effect of Transient Helicity of cMyb TAD on its Binding Affinity to the Kix Domain of CBP/p300
A Poosapati, W Borcherds, MD Carbtree, SL Shammas, J Clarke, GW Daughdrill
– FASEB JOURNAL
(2017)
31,
Cotranslational folding of spectrin domains via partially structured states.
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
– Nature Structural & Molecular Biology
(2017)
24,
221
What Encodes Coupled Folding and Binding Reactions: IDPS or Partner Proteins?
MD Crabtree, CATF Mendonca, Q Bubb, SL Shammas, J Clarke
– Biophysical Journal
(2017)
112,
481A
Editorial overview: Protein Folding and Binding, Complexity Comes of Age
J Clarke, RV Pappu
– Current opinion in structural biology
(2017)
42,
v
Protein folding - on and off the ribosome: Using Physics and Chemistry to understand Biology
J Clarke
– PROTEIN SCIENCE
(2016)
25,
175
GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins.
TS Harmon, MD Crabtree, SL Shammas, AE Posey, J Clarke, RV Pappu
– Protein Engineering Design and Selection
(2016)
29,
339
The Role of Disorder in Protein Folding
J Clarke
– BIOPHYSICAL JOURNAL
(2016)
110,
196A
Plasticity of Nucleoporin Nuclear Transport Receptor Interactions - Molecular Description of a Highly Dynamic, Ultrafast Interaction Mechanism
IV Aramburu, D Mercadante, S Milles, M Ringkjobing, N Banterle, C Koehler, S Tyagi, J Clarke, SL Shammas, M Blackledge, F Graeter, EA Lemke
– BIOPHYSICAL JOURNAL
(2016)
110,
357A
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
SL Shammas, MD Crabtree, L Dahal, BIM Wicky, J Clarke
– J Biol Chem
(2016)
291,
6689
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
RG Smock, I Yadid, O Dym, J Clarke, DS Tawfik
– Cell
(2016)
164,
476
Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors
S Milles, D Mercadante, IV Aramburu, MR Jensen, N Banterle, C Koehler, S Tyagi, J Clarke, SL Shammas, M Blackledge, F Gräter, EA Lemke
– Cell
(2015)
163,
734
The response of greek key proteins to changes in connectivity depends on the nature of their secondary structure
KR Kemplen, D De Sancho, J Clarke
– Journal of molecular biology
(2014)
427,
2159
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein.
DT Gruszka, F Whelan, OE Farrance, HKH Fung, E Paci, CM Jeffries, DI Svergun, C Baldock, CG Baumann, DJ Brockwell, JR Potts, J Clarke
– Nature Communications
(2015)
6,
7271
Transient misfolding dominates multidomain protein folding.
A Borgia, KR Kemplen, MB Borgia, A Soranno, S Shammas, B Wunderlich, D Nettels, RB Best, J Clarke, B Schuler
– Nature Communications
(2015)
6,
8861
Evolution of oligomeric state through allosteric pathways that mimic ligand binding
T Perica, Y Kondo, SP Tiwari, SH McLaughlin, KR Kemplen, X Zhang, A Steward, N Reuter, J Clarke, SA Teichmann
– Science
(2014)
346,
1254346
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein.
JM Rogers, V Oleinikovas, SL Shammas, CT Wong, D De Sancho, CM Baker, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
15420