Research Background: PhD and initial post-doctoral research on the use of NMR to study biological molecules and their interactions. Subsequent diverse experience in the pharmaceutical industry (GSK) applying solid state and liquid state NMR and MRI to drug polymorphism, drug receptor characterization, and drug action in biological models of disease.
Research Interests
Current interests focus on solid state NMR to characterize biomaterial structure using cell culture methods and isotope labelling, but also including drug product and timber product characterization.
Teaching
Supporting undergraduate and postgraduate research projects.
Publications
An electrophysiological and spectroscopic study of the properties and structure of biological calcium channels. Investigations of a model ion channel.
– Biochimica et Biophysica Acta (BBA) - Biomembranes
(1992)
1106,
264
(doi: 10.1016/0005-2736(92)90005-7)
A 15N nuclear magnetic resonance study of the biosynthesis of quinoxaline antibiotics
– Biochimica et Biophysica Acta
(1984)
798,
111
(doi: 10.1016/0304-4165(84)90017-5)
APPLICATION OF H-1 SPECTRAL EDITING TECHNIQUES TO STUDY ASPECTS OF THE BIOSYNTHESIS OF THE ANTIBIOTIC VANCOMYCIN
– Journal of Magnetic Resonance (1969)
(1984)
56,
279
(doi: 10.1016/0022-2364(84)90105-7)
Analysis of some pulse sequences that employ an intermediate J-ordered state involving a pair of scalar-coupled spin-32 and Spin-12 nuclei
– Journal of Magnetic Resonance (1969)
(1983)
54,
458
(doi: 10.1016/0022-2364(83)90325-6)
A 1 H nOe and CD study of the salt-concentration dependence of the structure of d(G-C) 5
– Nucleic Acids Res
(1983)
11,
3779
(doi: 10.1093/nar/11.11.3779)
The structure of a toxic octapeptide from the larvae of sawfly
– Journal of the Chemical Society, Perkin Transactions 1
(1983)
1869
(doi: 10.1039/p19830001869)
Application of a simple technique for the sole observation of n.m.r. resonances of protons which are directly bonded to nitrogen
– Chemical Communications
(1983)
218
(doi: 10.1039/c39830000218)
SOLUTION CONFORMATIONS OF 2 SYNTHETIC ANALOGS OF QUINOXALINE ANTIBIOTICS
– J CHEM SOC PERK T 1
(1982)
1041
(doi: 10.1039/p19820001041)
In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR
– Chemical Communications
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