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Currently displaying 121 - 140 of 573 publications

Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes using novel waveform parameters and a modified random forest algorithm

H Yang, O Obrezanova, A Pointon, W Stebbeds, J Francis, KA Beattie, P Clements, JS Harvey, GF Smith, A Bender

– TOXICOLOGY LETTERS

(2021)

350,

S61

(link to publication)

Opsins and gonadal circadian rhythm in the swordfish (Xiphias gladius) ovary: Their potential roles in puberty and reproductive seasonality

D Basili, G Gioacchini, V Todisco, M Candelma, L Marisaldi, L Pappalardo, O Carnevali

– General and comparative endocrinology

(2020)

303,

113707

(doi: 10.1016/j.ygcen.2020.113707)

De novo transcriptome assembly, functional annotation and characterization of the Atlantic bluefin tuna (Thunnus thynnus) larval stage

L Marisaldi, D Basili, G Gioacchini, A Canapa, O Carnevali

– Marine genomics

(2020)

58,

100834

(doi: 10.1016/j.margen.2020.100834)

Systematic Analysis of Protein Targets Associated with Adverse Events of Drugs from Clinical Trials and Postmarketing Reports.

IA Smit, AM Afzal, CHG Allen, F Svensson, T Hanser, A Bender

– Chem Res Toxicol

(2020)

34,

365

(doi: 10.1021/acs.chemrestox.0c00294)

New Associations Between Drug-Induced Adverse Events in Animal Models and Humans Reveal Novel Candidate Safety Targets

KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, SJ Hughes, A Bender

– Chemical research in toxicology

(2020)

34,

438

(doi: 10.1021/acs.chemrestox.0c00311)

Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet.

A Bender, I Cortés-Ciriano

– Drug Discov Today

(2020)

26,

511

(doi: 10.1016/j.drudis.2020.12.009)

5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

W Mahy, NJ Willis, Y Zhao, HL Woodward, F Svensson, J Sipthorp, L Vecchia, RR Ruza, J Hillier, S Kjær, S Frew, A Monaghan, M Bictash, PC Salinas, P Whiting, J-P Vincent, EY Jones, PV Fish

– Journal of medicinal chemistry

(2020)

63,

12942

(doi: 10.1021/acs.jmedchem.0c01391)

Network integration and modelling of dynamic drug responses at multi-omics levels

N Selevsek, F Caiment, R Nudischer, H Gmuender, I Agarkova, FL Atkinson, I Bachmann, V Baier, G Barel, C Bauer, S Boerno, N Bosc, O Clayton, H Cordes, S Deeb, S Gotta, P Guye, A Hersey, FMI Hunter, L Kunz, A Lewalle, M Lienhard, J Merken, J Minguet, B Oliveira, C Pluess, U Sarkans, Y Schrooders, J Schuchhardt, I Smit, C Thiel, B Timmermann, M Verheijen, T Wittenberger, W Wolski, A Zerck, S Heymans, L Kuepfer, A Roth, R Schlapbach, S Niederer, R Herwig, J Kleinjans

– Communications Biology

(2020)

573

(doi: 10.1038/s42003-020-01302-8)

Comparison of Scaling Methods to Obtain Calibrated Probabilities of Activity for Protein-Ligand Predictions

LH Mervin, AM Afzal, O Engkvist, A Bender

– Journal of chemical information and modeling

(2020)

60,

4546

(doi: 10.1021/acs.jcim.0c00476)

Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells

L-L Pruteanu, L Kopanitsa, D Módos, E Kletnieks, E Samarova, A Bender, LD Gomez, DS Bailey

– PLoS One

(2020)

15,

e0239551

(doi: 10.1371/journal.pone.0239551)

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

N Han, W Hwang, K Tzelepis, P Schmerer, E Yankova, M MacMahon, W Lei, N Katritsis, A Liu, A Schuldt, R Harris, K Chapman, F McCaughan, F Weber, T Kouzarides

(2020)

(doi: 10.1101/2020.08.24.265496)

Screening of a Custom-Designed Acid Fragment Library Identifies 1‑Phenylpyrroles and 1‑Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

W Mahy, M Patel, D Steadman, HL Woodward, BN Atkinson, F Svensson, NJ Willis, A Flint, D Papatheodorou, Y Zhao, L Vecchia, RR Ruza, J Hillier, S Frew, A Monaghan, A Costa, M Bictash, MW Walter, EY Jones, PV Fish

– Journal of medicinal chemistry

(2020)

63,

9464

(doi: 10.1021/acs.jmedchem.0c00660)

Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding.

GHS Dreiman, M Bictash, PV Fish, L Griffin, F Svensson

– SLAS Discovery

(2020)

26,

257

(doi: 10.1177/2472555220949495)

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.

MJ Burton, J Cresser-Brown, M Thomas, N Portolano, J Basran, SL Freeman, H Kwon, AR Bottrill, MJ Llansola-Portoles, AA Pascal, R Jukes-Jones, T Chernova, R Schmid, NW Davies, NM Storey, P Dorlet, PCE Moody, JS Mitcheson, EL Raven

– J Biol Chem

(2020)

295,

13277

(doi: 10.1074/jbc.ra120.014150)

Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil.

T Li, C Zhou, N Zheng, H Yang, G Kuang, X Shao, Z Li, J Cheng

– Biophys Chem

(2020)

265,

106426

(doi: 10.1016/j.bpc.2020.106426)