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Data-Driven Drug Discovery and Molecular Informatics

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  • Currently displaying 541 - 560 of 574 publications
Evolved Cellular Automata for Protein Secondary Structure Prediction Imitate the Determinants for Folding Observed in Nature
P Chopra, A Bender
– In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation
(2007)
7,
87
In silico target fishing: Predicting biological targets from chemical structure
JL Jenkins, A Bender, JW Davies
– Drug Discovery Today: Technologies
(2006)
3,
413
Chapter 9 Molecular Similarity: Advances in Methods, Applications and Validations in Virtual Screening and QSAR.
A Bender, JL Jenkins, Q Li, SE Adams, EO Cannon, RC Glen
– Annual reports in computational chemistry
(2006)
2,
141
Bridging chemical and biological space: "Target fishing" using 2D and 3D molecular descriptors
JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick
– Journal of Medicinal Chemistry
(2006)
49,
6802
Melting Point Prediction Employing k-Nearest Neighbor Algorithms and Genetic Parameter Optimization
F Nigsch, A Bender, B van Buuren, J Tissen, E Nigsch, JBO Mitchell
– Journal of Chemical Information and Modeling
(2006)
46,
2412
Chemoinformatics-based classification of prohibited substances employed for doping in sport
EO Cannon, A Bender, DS Palmer, JBO Mitchell
– Journal of chemical information and modeling
(2006)
46,
2369
Bridging chemical and biological space: "Target Fishing" using 2D and 3D molecular descriptors
JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2006)
232,
293
"Bayes affinity fingerprints" Improve retrieval rates in virtual screening and define orthogonal bioactivity space: When are multitarget drugs a feasible concept?
A Bender, JL Jenkins, M Glick, Z Deng, JH Nettles, JW Davies
– J Chem Inf Model
(2006)
46,
2445
Synthesis and enzyme activity of SiO2 monolithic carrier with double-pore structure by addition of starch/PEG
HB Yang, Q Chen, L Song, RF Ye, FZ Hou, JY Lu
– Wuji Cailiao Xuebao/Journal of Inorganic Materials
(2006)
21,
1154
Skeletal diversity construction via a branching synthetic strategy
EE Wyatt, S Fergus, W Galloway, A Bender, DJ Fox, AT Plowright, AS Jessiman, M Welch, DR Spring
– Chem Commun (Camb)
(2006)
3296
Circular fingerprints: Flexible molecular descriptors with applications from physical chemistry to ADME (vol 9, pg 199, 2006)
RC Glen, A Bender, CH Arnby, L Carlsson, S Boyer, J Smith
– IDRUGS
(2006)
9,
311
Virtual screening: The king (quite often) has no clothes
RC Glen, A Bender
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2006)
231,
Analysis of Activity Space by Fragment Fingerprints, 2D Descriptors, and Multitarget Dependent Transformation of 2D Descriptors
A Givehchi, A Bender, RC Glen
– J Chem Inf Model
(2006)
46,
1078
Circular fingerprints: flexible molecular descriptors with applications from physical chemistry to ADME.
RC Glem, A Bender, CH Arnby, L Carlsson, S Boyer, J Smith
– IDrugs
(2006)
9,
199
Harvesting Chemical Information from the Internet Using a Distributed Approach:  ChemXtreme
M Karthikeyan, S Krishnan, AK Pandey, A Bender
– Journal of chemical information and modeling
(2006)
46,
452
Characterizing Bitterness:  Identification of Key Structural Features and Development of a Classification Model
S Rodgers, RC Glen, A Bender
– Journal of Chemical Information and Modeling
(2006)
46,
569
Synthesis of monolithic silica materials with meso macro-porous double-pore structure
H Yang, J Li, Q Chen, L Song, J Lu
– Kuei Suan Jen Hsueh Pao/ Journal of the Chinese Ceramic Society
(2006)
34,
21
Diversity Oriented Synthesis: A Challenge for Synthetic Chemists
A Bender, S Fergus, WRJD Galloway, FG Glansdorp, DM Marsden, RL Nicholson, RJ Spandl, GL Thomas, EE Wyatt, RC Glen, DR Spring
– Ernst Schering Research Foundation workshop
(2006)
58,
47
Molecular similarity searching using COSMO screening charges (COSMO/3PP)
A Bender, A Klamt, K Wichmann, M Thormann, RC Glen
– Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
(2005)
3695,
175
Screening for dihydrofolate reductase inhibitors using MOLPRINT 2D, a fast fragment-based method employing the naive Bayesian classifier: Limitations of the descriptor and the importance of balanced chemistry in training and test sets
A Bender, HY Mussa, RC Glen
– Journal of biomolecular screening
(2005)
10,
658