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Data-Driven Drug Discovery and Molecular Informatics

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  • Currently displaying 401 - 420 of 574 publications
CanSAR: Updated cancer research and drug discovery knowledgebase
KC Bulusu, JE Tym, EA Coker, AC Schierz, B Al-Lazikani
– Nucleic Acids Research
(2014)
42,
Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: The importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases
S Paricharak, T Klenka, M Augustin, UA Patel, A Bender
– J Cheminform
(2013)
5,
49
How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space
A Koutsoukas, S Paricharak, WRJD Galloway, DR Spring, AP Ijzerman, RC Glen, D Marcus, A Bender
– J Chem Inf Model
(2013)
54,
230
canSAR: updated cancer research and drug discovery knowledgebase.
KC Bulusu, JE Tym, EA Coker, AC Schierz, B Al-Lazikani
– Nucleic Acids Research
(2013)
42,
D1040
Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Molecular Cancer Therapeutics
(2013)
12,
b96
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Chemistry & Biology
(2013)
20,
1399
International chemical identifier for reactions (RInChI).
G Grethe, JM Goodman, CH Allen
– Journal of Cheminformatics
(2013)
5,
45
Experimental Confirmation of New Drug-Target Interactions Predicted by Drug Profile Matching
L Végner, Á Peragovics, L Tombor, B Jelinek, P Czobor, A Bender, Z Simon, A Málnási-Csizmadia
– J Med Chem
(2013)
56,
8377
Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts
S Liggi, G Drakakis, AE Hendry, KM Hanson, SC Brewerton, GN Wheeler, MJ Bodkin, DA Evans, A Bender
– Mol Inform
(2013)
32,
1009
Temperature measurements with two different IR sensors in a continuous-flow microwave heated system
J Rydfjord, F Svensson, M Fagrell, J Sävmarker, M Thulin, M Larhed
– Beilstein Journal of Organic Chemistry
(2013)
9,
2079
Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): Comparative study of 13 amino acid descriptor sets
GJ van Westen, RF Swier, I Cortes-Ciriano, JK Wegner, JP Overington, AP Ijzerman, HW van Vlijmen, A Bender
– J Cheminform
(2013)
5,
42
Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets
GJ van Westen, RF Swier, JK Wegner, AP Ijzerman, HW van Vlijmen, A Bender
– Journal of Cheminformatics
(2013)
5,
41
Decarboxylative Palladium(II)‐Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation
J Rydfjord, F Svensson, A Trejos, PJR Sjöberg, C Sköld, J Sävmarker, LR Odell, M Larhed
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2013)
19,
13803
Diversity selection of compounds based on 'protein affinity fingerprints' improves sampling of bioactive chemical space
HP Nguyen, A Koutsoukas, F Mohd Fauzi, G Drakakis, M Maciejewski, RC Glen, A Bender
– Chemical Biology & Drug Design
(2013)
82,
252
Reconstruction and comparison of cellular signaling pathway resources for the systems-level analysis of cross-talks
M Pálfy, L Földvári-Nagy, D Módos, K Lenti, T Korcsmáros
(2013)
1,
463
In silico target predictions: defining a benchmarking data set and comparison of performance of the multiclass Naïve Bayes and Parzen-Rosenblatt window.
A Koutsoukas, R Lowe, Y Kalantarmotamedi, HY Mussa, W Klaffke, JBO Mitchell, RC Glen, A Bender
– J Chem Inf Model
(2013)
53,
1957
Computer-aided (in silico) approaches in the mode-of-action analysis and safety assessment of Ostarine and 4-methylamphetamine
F Mohd Fauzi, A Koutsoukas, A Cunningham, A Gallegos, R Sedefov, A Bender
– Human Psychopharmacology: Clinical and Experimental
(2013)
28,
365
Adaptation and learning of molecular networks as a description of cancer development at the systems-level: potential use in anti-cancer therapies.
DM Gyurkó, DV Veres, D Módos, K Lenti, T Korcsmáros, P Csermely
– Seminars in Cancer Biology
(2013)
23,
262
NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2
D Türei, D Papp, D Fazekas, L Földvári-Nagy, D Módos, K Lenti, P Csermely, T Korcsmáros
– Oxidative medicine and cellular longevity
(2013)
2013,
1
In silico target prediction: identification of on- and off-targets for crop protection agents
RK Chiddarwar, A Bender, S Rohrer
– Journal of Cheminformatics
(2013)
5,
p18