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Data-Driven Drug Discovery and Molecular Informatics

Lewis Howard Mervin

Research Associate

Lewis joined the Bender research group at the Centre for Molecular Informatics in 2013 through a BBSRC/AstraZeneca CASE Studentship, following an undergraduate degree in Biology and Computing Science at the University of Manchester. His doctoral research involves the development of target prediction & Mechanism-of-Action (MoA) protocols which are publicly available via GitHub. This is an area of research which will be continued subsequently also in his postdoctoral project.

Publications

Leveraging heterogeneous data from GHS toxicity annotations, molecular and protein target descriptors and Tox21 assay readouts to predict and rationalise acute toxicity
CHG Allen, LH Mervin, SY Mahmoud, A Bender
– J Cheminform
(2019)
11,
36
(doi: 10.1186/s13321-019-0356-5)
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
HR Noori, LH Mervin, V Bokharaie, Ö Durmus, L Egenrieder, S Fritze, B Gruhlke, G Reinhardt, H-H Schabel, S Staudenmaier, NK Logothetis, A Bender, R Spanagel
– Nat Commun
(2018)
9,
4699
(doi: 10.1038/s41467-018-07239-1)
Understanding and predicting disease relationships through similarity fusion.
E Oerton, I Roberts, PSH Lewis, T Guilliams, A Bender
– Bioinformatics (Oxford, England)
(2018)
35,
1213
(doi: 10.1093/bioinformatics/bty754)
Extending in Silico Protein Target Prediction Models to Include Functional Effects.
LH Mervin, AM Afzal, L Brive, O Engkvist, A Bender
– Frontiers in Pharmacology
(2018)
9,
613
(doi: 10.3389/fphar.2018.00613)
Computer-aided design of multi-target ligands at A
L Kalash, C Val, J Azuaje, MI Loza, F Svensson, A Zoufir, L Mervin, G Ladds, J Brea, R Glen, E Sotelo, A Bender
– Journal of Cheminformatics
(2017)
9,
67
(doi: 10.1186/s13321-017-0249-4)
Towards the mode of action of Strobilanthes crispus through integrated computational and experimental analyses
KK Wong, LH Mervin, A Mazzolari, A Bender, NS Yaacob
– Journal of Plant Biochemistry and Biotechnology
(2017)
26,
451
(doi: 10.1007/s13562-017-0407-9)
Orthologue chemical space and its influence on target prediction
LH Mervin
– Bioinformatics
(2017)
34,
72
(doi: 10.1093/bioinformatics/btx525)
Toward Understanding the Cold, Hot, and Neutral Nature of Chinese Medicines Using in Silico Mode-of-Action Analysis.
X Fu, LH Mervin, X Li, H Yu, J Li, SZ Mohamad Zobir, A Zoufir, Y Zhou, Y Song, Z Wang, A Bender
– J Chem Inf Model
(2017)
57,
468
(doi: 10.1021/acs.jcim.6b00725)
Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer.
A Sebastian, V Pandey, CD Mohan, YT Chia, S Rangappa, J Mathai, CP Baburajeev, S Paricharak, LH Mervin, KC Bulusu, JE Fuchs, A Bender, S Yamada, Basappa, PE Lobie, KS Rangappa
– ACS omega
(2016)
1,
1412
(doi: 10.1021/acsomega.6b00251)
Current trends in drug sensitivity prediction
I Cortes-Ciriano, LH Mervin, A Bender
– Current pharmaceutical design
(2016)
22,
6918
(doi: 10.2174/1381612822666161026154430)
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Telephone number

01223 763078 (shared)

Research Interests

Study at Cambridge

About the University

Research at Cambridge