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Data-Driven Drug Discovery and Molecular Informatics

Dr Isidro Cortes Ciriano

Research Fellow

Publications

A decision theoretic approach to model evaluation in computational drug discovery
O Watson, I Cortes-Ciriano, A Taylor, JA Watson
(2018)
(link to publication)
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
I Cortés-Ciriano, J-K Lee, R Xi, D Jain, Y Jung, L Yang, D Gordenin, L Klimczak, C-Z Zhang, D Pellman, P Park, on behalf of the PCAWG Structural Variation Working Group, the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
(2018)
333617
(doi: 10.1101/333617)
Conformal Regression for Quantitative Structure-Activity Relationship Modeling-Quantifying Prediction Uncertainty.
F Svensson, N Aniceto, U Norinder, I Cortes-Ciriano, O Spjuth, L Carlsson, A Bender
– Journal of chemical information and modeling
(2018)
58,
1132
(doi: 10.1021/acs.jcim.8b00054)
Comprehensive Characterization of Cancer Driver Genes and Mutations
MH Bailey, C Tokheim, E Porta-Pardo, S Sengupta, D Bertrand, A Weerasinghe, A Colaprico, MC Wendl, J Kim, B Reardon, PK-S Ng, KJ Jeong, S Cao, Z Wang, J Gao, Q Gao, F Wang, EM Liu, L Mularoni, C Rubio-Perez, N Nagarajan, I Cortés-Ciriano, DC Zhou, W-W Liang, JM Hess, VD Yellapantula, D Tamborero, A Gonzalez-Perez, C Suphavilai, JY Ko, E Khurana, PJ Park, EM Van Allen, H Liang, MC3 Working Group, Cancer Genome Atlas Research Network, MS Lawrence, A Godzik, N Lopez-Bigas, J Stuart, D Wheeler, G Getz, K Chen, AJ Lazar, GB Mills, R Karchin, L Ding
– Cell
(2018)
173,
371
(doi: 10.1016/j.cell.2018.02.060)
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
L Ding, MH Bailey, E Porta-Pardo, V Thorsson, A Colaprico, D Bertrand, DL Gibbs, A Weerasinghe, K-L Huang, C Tokheim, I Cortés-Ciriano, R Jayasinghe, F Chen, L Yu, S Sun, C Olsen, J Kim, AM Taylor, AD Cherniack, R Akbani, C Suphavilai, N Nagarajan, JM Stuart, GB Mills, MA Wyczalkowski, BG Vincent, CM Hutter, JC Zenklusen, KA Hoadley, MC Wendl, L Shmulevich, AJ Lazar, DA Wheeler, G Getz, Cancer Genome Atlas Research Network
– Cell
(2018)
173,
305
(doi: 10.1016/j.cell.2018.03.033)
Genomic footprints of activated telomere maintenance mechanisms in cancer
L Sieverling, C Hong, S Koser, P Ginsbach, K Kleinheinz, B Hutter, D Braun, I Cortés-Ciriano, R Xi, R Kabbe, P Park, R Eils, M Schlesner, K Rippe, DTW Jones, B Brors, L Feuerbach, on behalf of the PCAWG Structural Variation Working Group, PCAWG SNV Calling Working Group, PCAWG Drivers and Functional Interpretation Group, PCAWG Evolution and Heterogeneity Working Group, PCAWG Technical Working Group, and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
(2017)
157560
(doi: 10.1101/157560)
A molecular portrait of microsatellite instability across multiple cancers
I Cortes-Ciriano, S Lee, W-Y Park, T-M Kim, PJ Park
– Nat Commun
(2017)
8,
15180
(doi: 10.1038/ncomms15180)
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.
MJ McConnell, JV Moran, A Abyzov, S Akbarian, T Bae, I Cortes-Ciriano, JA Erwin, L Fasching, DA Flasch, D Freed, J Ganz, AE Jaffe, KY Kwan, M Kwon, MA Lodato, RE Mills, ACM Paquola, RE Rodin, C Rosenbluh, N Sestan, MA Sherman, JH Shin, S Song, RE Straub, J Thorpe, DR Weinberger, AE Urban, B Zhou, FH Gage, T Lehner, G Senthil, CA Walsh, A Chess, E Courchesne, JG Gleeson, JM Kidd, PJ Park, J Pevsner, FM Vaccarino, Brain Somatic Mosaicism Network
– Science
(2017)
356,
eaal1641
(doi: 10.1126/science.aal1641)
Cancer Cell Line Profiler (CCLP): a webserver for the prediction of compound activity across the NCI60 panel
I Cortés-Ciriano, D Murrell, B Chetrit, A Bender, T Malliavin, P Ballester
(2017)
105478
(doi: 10.1101/105478)
Current Trends in Drug Sensitivity Prediction.
I Cortes-Ciriano, LH Mervin, A Bender
– Current Pharmaceutical Design
(2016)
22,
6918
(doi: 10.2174/1381612822666161026154430)
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Research at Cambridge