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Data-Driven Drug Discovery and Molecular Informatics

Dr Fredrik Svensson

Postdoctoral research fellow working in the Bender group.

Publications

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
D Steadman, BN Atkinson, Y Zhao, NJ Willis, S Frew, A Monaghan, C Patel, E Armstrong, K Costelloe, L Magno, M Bictash, EY Jones, PV Fish, F Svensson
– Journal of medicinal chemistry
(2021)
65,
562
(doi: 10.1021/acs.jmedchem.1c01735)
Synergy conformal prediction applied to large-scale bioactivity datasets and in federated learning
U Norinder, O Spjuth, F Svensson
– Journal of cheminformatics
(2021)
13,
77
(doi: 10.1186/s13321-021-00555-7)
Structural Insights into Notum Covalent Inhibition.
Y Zhao, F Svensson, D Steadman, S Frew, A Monaghan, M Bictash, T Moreira, R Chalk, W Lu, PV Fish, EY Jones
– Journal of medicinal chemistry
(2021)
64,
11354
(doi: 10.1021/acs.jmedchem.1c00701)
Deep Learning-Based Conformal Prediction of Toxicity.
J Zhang, U Norinder, F Svensson
– Journal of Chemical Information and Modeling
(2021)
61,
2648
(doi: 10.1021/acs.jcim.1c00208)
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
ED Bayle, F Svensson, BN Atkinson, D Steadman, NJ Willis, HL Woodward, P Whiting, J-P Vincent, PV Fish
– Journal of Medicinal Chemistry
(2021)
64,
4289
(doi: 10.1021/acs.jmedchem.0c01974)
Assessing the Calibration in Toxicological in Vitro Models with Conformal Prediction
A Morger, F Svensson, SA McShane, N Gauraha, U Norinder, O Spjuth, A Volkamer
(2021)
(doi: 10.21203/rs.3.rs-220364/v1)
Systematic Analysis of Protein Targets Associated with Adverse Events of Drugs from Clinical Trials and Postmarketing Reports.
IA Smit, AM Afzal, CHG Allen, F Svensson, T Hanser, A Bender
– Chem Res Toxicol
(2020)
34,
365
(doi: 10.1021/acs.chemrestox.0c00294)
Correction to “Using Predicted Bioactivity Profiles to Improve Predictive Modeling”
U Norinder, O Spjuth, F Svensson
– Journal of Chemical Information and Modeling
(2020)
60,
6722
(doi: 10.1021/acs.jcim.0c01327)
5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
W Mahy, NJ Willis, Y Zhao, HL Woodward, F Svensson, J Sipthorp, L Vecchia, RR Ruza, J Hillier, S Kjær, S Frew, A Monaghan, M Bictash, PC Salinas, P Whiting, J-P Vincent, EY Jones, PV Fish
– J Med Chem
(2020)
63,
12942
(doi: 10.1021/acs.jmedchem.0c01391)
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding.
GHS Dreiman, M Bictash, PV Fish, L Griffin, F Svensson
– SLAS Discovery
(2020)
26,
257
(doi: 10.1177/2472555220949495)
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Study at Cambridge

About the University

Research at Cambridge