Research Associate
Lewis joined the Bender research group at the Centre for Molecular Informatics in 2013 through a BBSRC/AstraZeneca CASE Studentship, following an undergraduate degree in Biology and Computing Science at the University of Manchester. His doctoral research involves the development of target prediction & Mechanism-of-Action (MoA) protocols which are publicly available via GitHub. This is an area of research which will be continued subsequently also in his postdoctoral project.
Publications
Leveraging heterogeneous data from GHS toxicity annotations, molecular and protein target descriptors and Tox21 assay readouts to predict and rationalise acute toxicity
– Journal of Cheminformatics
(2019)
11,
36
(doi: 10.1186/s13321-019-0356-5)
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
– Nature communications
(2018)
9,
4699
(doi: 10.1038/s41467-018-07239-1)
Understanding and predicting disease relationships through similarity fusion
– Bioinformatics (Oxford, England)
(2018)
35,
1213
Computer-aided design of multi-target ligands at A
– J Cheminform
(2017)
9,
67
(doi: 10.1186/s13321-017-0249-4)
Towards the mode of action of Strobilanthes crispus through integrated computational and experimental analyses
– Journal of Plant Biochemistry and Biotechnology
(2017)
26,
451
(doi: 10.1007/s13562-017-0407-9)
Orthologue chemical space and its influence on target prediction.
– Bioinformatics
(2017)
34,
72
Toward Understanding the Cold, Hot, and Neutral Nature of Chinese Medicines Using in Silico Mode-of-Action Analysis.
– J Chem Inf Model
(2017)
57,
468
(doi: 10.1021/acs.jcim.6b00725)
Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer
– ACS omega
(2016)
1,
1412
(doi: 10.1021/acsomega.6b00251)
Current trends in drug sensitivity prediction
– Current pharmaceutical design
(2016)
22,
6918
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