Centre for Experimental Biophysical Chemistry

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  • Currently displaying 101 - 120 of 1107 publications
Author(s)
Publication title
Journal Name
Publication year
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
(2024)
(doi: 10.7554/eLife.92350)
Biomolecular condensates with complex architectures via controlled nucleation
NA Erkamp, MAM Verwiel, D Qian, T Sneideris, FA Spaepen, DA Weitz, JCM van Hest, TPJ Knowles
Nature Chemical Engineering
(2024)
1
(doi: 10.1038/s44286-024-00077-7)
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Z Xia, EE Prescott, A Urbanek, HE Wareing, MC King, A Olerinyova, H Dakin, T Leah, KA Barnes, MM Matuszyk, E Dimou, E Hidari, YP Zhang, JYL Lam, JSH Danial, MR Strickland, H Jiang, P Thornton, DC Crowther, S Ohtonen, M Gómez-Budia, SM Bell, L Ferraiuolo, H Mortiboys, A Higginbottom, SB Wharton, DM Holtzman, T Malm, RT Ranasinghe, D Klenerman, S De
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-49028-z)
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces.
A Dear, D Thacker, S Wennmalm, L Ortigosa-Pascual, EA Andrzejewska, G Meisl, S Linse, T Knowles
ACS chemical neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00127)
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralisation
H Ausserwöger, R Scrutton, C Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, K Saar, A Białek, M Oeller, G Krainer, T Franzmann, S Wittmann, J Iglesias-Artola, G Invernizzi, A Hyman, S Alberti, N Lorenzen, T Knowles
(2024)
(doi: 10.1101/2024.05.23.595321)
Solutes unmask differences in clustering versus phase separation of FET proteins
M Kar, LT Vogel, G Chauhan, S Felekyan, H Ausserwöger, TJ Welsh, F Dar, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-48775-3)
An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions.
G Cereghetti, VM Kissling, LM Koch, A Arm, CC Schmidt, Y Thüringer, N Zamboni, P Afanasyev, M Linsenmeier, C Eichmann, S Kroschwald, J Zhou, Y Cao, DM Pfizenmaier, T Wiegand, R Cadalbert, G Gupta, D Boehringer, TPJ Knowles, R Mezzenga, P Arosio, R Riek, M Peter
Developmental Cell
(2024)
59
(doi: 10.1016/j.devcel.2024.04.018)
Single-molecule characterization of salivary protein aggregates from Parkinson's disease patients: a pilot study.
M Furlepa, YP Zhang, E Lobanova, L Kahanawita, G Vivacqua, CH Williams-Gray, D Klenerman
Brain Commun
(2024)
6
(doi: 10.1093/braincomms/fcae178)
Polysaccharide functionalization reduces lipid vesicle stiffness
K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2317227121)
Single-Molecule Stoichiometry of Supramolecular Complexes.
A McLean, RL Sala, BW Longbottom, AR Carr, JA McCune, SF Lee, OA Scherman
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c00611)
Kinetic models reveal the interplay of protein production and aggregation
J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, TPJ Knowles
Chem Sci
(2024)
15
(doi: 10.1039/d4sc00088a)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-47585-x)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2024)
(doi: 10.7554/elife.92350.2)
Maximum entropy determination of mammalian proteome dynamics.
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
Proc Natl Acad Sci U S A
(2024)
121
(doi: 10.1073/pnas.2313107121)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
Chem Sci
(2024)
15
(doi: 10.1039/d3sc05661a)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
(doi: 10.1101/2024.04.16.589709)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
Nat Chem Biol
(2024)
20
(doi: 10.1038/s41589-024-01580-x)
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202317756)
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie International Edition
(2024)
136
(doi: 10.1002/ange.202317756)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
J Phys Chem B
(2024)
128
(doi: 10.1021/acs.jpcb.4c00174)
Yusuf Hamied Department of Chemistry
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