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  • Currently displaying 361 - 380 of 1104 publications
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2009.13413)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
– Nature Structural & Molecular Biology
(2020)
27,
1125
(doi: 10.1038/s41594-020-0505-6)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors
M Schneider, M Emmenegger, C Xu, IC Morales, G Meisl, P Turelli, C Zografou, M Zimmermann, B Frey, S Fiedler, V Denninger, R Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, T Knowles, A Aguzzi
– medRxiv
(2020)
2020.09.20.20196907
(doi: 10.1101/2020.09.20.20196907)
A Comparative Photophysical Study of Structural Modifications of Thioflavin T‑Inspired Fluorophores
L-M Needham, J Weber, CM Pearson, DT Do, F Gorka, G Lyu, SE Bohndiek, TN Snaddon, SF Lee
– J Phys Chem Lett
(2020)
11,
8406
(doi: 10.1021/acs.jpclett.0c01549)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
– Light: Science & Applications
(2020)
9,
165
(doi: 10.1038/s41377-020-00401-9)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy.
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
– Light Sci Appl
(2020)
9,
165
(doi: 10.1038/s41377-020-00401-9)
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo
– Scientific Reports
(2020)
10,
15280
(doi: 10.1038/s41598-020-69626-3)
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
– Nat Nanotechnol
(2020)
15,
841
(doi: 10.1038/s41565-020-0731-4)
Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons
DR Whiten, PW Brownjohn, S Moore, S De, A Strano, Y Zuo, M Haneklaus, D Klenerman, FJ Livesey
– Brain communication
(2020)
2,
fcaa146
(doi: 10.1093/braincomms/fcaa146)
Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum
M Schneider, T Scheidt, A Priddey, C Xu, M Hu, S Devenish, G Meisl, C Dobson, V Kosmoliaptsis, T Knowles
– bioRxiv
(2020)
2020.09.14.296442
(doi: 10.1101/2020.09.14.296442)
Biomimetic peptide self-assembly for functional materials.
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
– Nat Rev Chem
(2020)
4,
615
(doi: 10.1038/s41570-020-0215-y)
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
24251
(doi: 10.1073/pnas.2006684117)
Single Molecule Light Field Microscopy
RR Sims, SA Rehman, MO Lenz, SI Benaissa, E Bruggeman, A Clark, EW Sanders, A Ponjavic, L Muresan, SF Lee, K O’Holleran
– Optica
(2020)
7,
1065
(doi: 10.1364/OPTICA.397172)
Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye
DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, S Boyle, DA Weitz, J Brenton, JD Buenrostro, C Thomas, TP Knowles
– Cancer Research
(2020)
80,
5879
(doi: 10.1158/1538-7445.am2020-5879)
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.
J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett
– Nanoscale
(2020)
12,
18663
(doi: 10.1039/d0nr01481h)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto
(2020)
2020.08.13.249862
(doi: 10.1101/2020.08.13.249862)
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Commun Biol
(2020)
3,
435
(doi: 10.1038/s42003-020-01140-8)
Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
– Small
(2020)
16,
2070178
(doi: 10.1002/smll.202070178)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of A beta 42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
– Nat Struct Mol Biol
(2020)
27,
886
(doi: 10.1038/s41594-020-0471-z)
Direct detection of whole bacteria using a nonlinear acoustic resonator
S Khobragade, C Da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
– Sensors and Actuators, B: Chemical
(2020)
316,
128086
(doi: 10.1016/j.snb.2020.128086)

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