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  • Currently displaying 1 - 20 of 1100 publications
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
– Proceedings of the National Academy of Sciences
(2025)
122,
e2412218122
(doi: 10.1073/pnas.2412218122)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
– Communications chemistry
(2025)
8,
133
(doi: 10.1038/s42004-025-01524-z)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
11,
eadq5396
(doi: 10.1126/sciadv.adq5396)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
– Alzheimer's & dementia : the journal of the Alzheimer's Association
(2025)
21,
e70086
(doi: 10.1002/alz.70086)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
– Nature Reviews Materials
(2025)
1
(doi: 10.1038/s41578-025-00793-3)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
– Nature communications
(2025)
16,
3463
(doi: 10.1038/s41467-025-58736-z)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
– Science advances
(2025)
11,
eadp8504
(doi: 10.1126/sciadv.adp8504)
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(doi: 10.1101/2025.04.02.645070)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, TJ Scheidt, D Thacker, E Axell, E Stemme, U Lapinska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, J Schmit, T Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(doi: 10.1101/2025.03.31.646415)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
– Science advances
(2025)
11,
eadv1971
(doi: 10.1126/sciadv.adv1971)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
– Communications Biology
(2025)
8,
466
(doi: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature Communications
(2025)
16,
2814
(doi: 10.1038/s41467-025-58142-5)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature communications
(2025)
16,
2814
(doi: 10.1038/s41467-025-58142-5)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
– Communications biology
(2025)
8,
466
(doi: 10.1038/s42003-025-07909-z)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide.
Z Toprakcioglu, AK Jayaram, TPJ Knowles
– RSC Chem Biol
(2025)
6,
809
(doi: 10.1039/d4cb00189c)
Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
(2025)
(doi: 10.1101/2025.03.04.641150)
A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
M Steindel, O Davis, K Neumann, L Pirvan, G Agsu, A Kranz, D Adhya, J Morf, S Yang, Z Zhang, J Fu, M Barile, A Wurmser, SE Strawbridge, I Mohorianu, P Madapura, B Huntly, B Göttgens, D Holcman, SA Samarajiwa, D Klenerman, K Anastassiadis, A Francis Stewart, S Basu
(2025)
(doi: 10.1101/2025.02.21.639010)
Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars
C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, H Ausserwöger, JR Morgan, TPJ Knowles, RV Pappu, D Milovanovic
– J Mol Biol
(2025)
437,
168987
(doi: 10.1016/j.jmb.2025.168987)
Kinetics of Amyloid Oligomer Formation
J Wei, G Meisl, AJ Dear, TCT Michaels, TPJ Knowles
– Annual review of biophysics
(2025)
54,
185
(doi: 10.1146/annurev-biophys-080124-122953)

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