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Dr Hyeryeong Lee

UKRI Research Fellow

I am currently working on development of a semi-artificial photosynthetic system powered by cyanobacteria, under the supervision of Dr. Jenny Zhang at the University of Cambridge. My research focuses on genetically engineering protein topologies within cyanobacterial cells to enhance their light-harvesting capability and bioenergy production. Prior to this, I earned my M.S. (2017) and Ph.D. (2022) degrees from the Gwangju Institute of Science and Technology, where I was honored with the Graduate Research Excellence Award, achieving 1st place upon Ph.D. graduation. My doctoral research centered on utilizing protein-engineering approaches to control the orientation of (multi-)enzymes on electrode surfaces, thereby enhancing enzymatic chain reaction rates and improving electrical communication at the enzyme-electrode interfaces. My academic journey has been supported by prestigious fellowships, including the Global Ph.D. Fellowship (GPF) and the Basic Science Research Fellowship, both funded by the National Research Foundation of Korea. Additionally, I was once selected as one of 15 nationwide representatives for the 9th Global Young Scientist Summit (GYSS) in Singapore, an opportunity that broadened my scientific perspective and network. In 2024, I joined the University of Cambridge after being awarded the Marie Curie Fellowship, expanding my expertise from protein-based electrochemistry to photosynthetic microbe-based "photobioelectrochemistry." My current research interests lie in biophotovoltaics, synthetic biology, cyanobacterial and protein engineering, photosystem modifications, and (photo)bioelectrochemistry.

Publications

Peptide sequence-driven direct electron transfer properties and binding behaviors of gold-binding peptide-fused glucose dehydrogenase on electrode.
H Lee, EM Lee, SS Reginald, IS Chang
– iScience
(2021)
24,
103373
(doi: 10.1016/j.isci.2021.103373)
Biosensing and electrochemical properties of flavin adenine dinucleotide (FAD)-Dependent glucose dehydrogenase (GDH) fused to a gold binding peptide.
H Lee, YS Lee, SS Reginald, S Baek, EM Lee, I-G Choi, IS Chang
– Biosens Bioelectron
(2020)
165,
112427
(doi: 10.1016/j.bios.2020.112427)
On Creating Multimedia Interfaces for Hybrid Biological-Digital Art Installations
C Castellanos, B Bello, H Lee, M Lee, YS Lee, IS Chang
(2020)
11961,
139
(doi: 10.1007/978-3-030-37731-1_12)
Dissolved carbon monoxide concentration monitoring platform based on direct electrical connection of CO dehydrogenase with electrically accessible surface structure
SS Reginald, H Lee, YS Lee, M Yasin, IS Chang
– Bioresour Technol
(2019)
297,
122436
(doi: 10.1016/j.biortech.2019.122436)
Electrocatalytic and Biosensing Properties of Aerobic Carbon Monoxide Dehydrogenase from Hydrogenophaga Pseudoflava Immobilized on Au Electrode towards Carbon Monoxide Oxidation
SS Reginald, YS Lee, H Lee, N Jang, IS Chang
– Electroanalysis
(2019)
31,
1635
(doi: 10.1002/elan.201800666)
Significant enhancement of direct electric communication across enzyme-electrode interface via nano-patterning of synthetic glucose dehydrogenase on spatially tunable gold nanoparticle (AuNP)-modified electrode
H Lee, YS Lee, SK Lee, S Baek, I-G Choi, J-H Jang, IS Chang
– Biosensors & bioelectronics
(2018)
126,
170
(doi: 10.1016/j.bios.2018.10.013)
Construction of Uniform Monolayer- and Orientation-Tunable Enzyme Electrode by a Synthetic Glucose Dehydrogenase without Electron-Transfer Subunit via Optimized Site-Specific Gold-Binding Peptide Capable of Direct Electron Transfer.
YS Lee, S Baek, H Lee, SS Reginald, Y Kim, H Kang, I-G Choi, IS Chang
– ACS Applied Materials & Interfaces
(2018)
10,
28615
(doi: 10.1021/acsami.8b08876)
pH-dependent ammonia removal pathways in microbial fuel cell system
T Kim, J An, H Lee, JK Jang, IS Chang
– Bioresour Technol
(2016)
215,
290
(doi: 10.1016/j.biortech.2016.03.167)
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