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The Scherman Group

 

Polymeric hydrogels

Modification of solution viscosity using multivalent polymers has been accomplished through dynamic cross-linking in water using CB[8]. These hydrogels, with extremely high water content (up to 99.75% water by weight), have also been prepared by utilising renewable cellulose derivatives. Their rapid formation and shear-induced flow properties make these materials perfectly suited for use as injectable hydrogels for delivery of therapeutics.

Related Publications 

Activation energies control the macroscopic properties of physically cross-linked materials
EA Appel, RA Forster, A Koutsioubas, C Toprakcioglu, OA Scherman – Angewandte Chemie - International Edition (2014) 53, 10038
The control of cargo release from physically crosslinked hydrogels by crosslink dynamics.
EA Appel, RA Forster, MJ Rowland, OA Scherman – Biomaterials (2014) 35, 9897
Dynamically crosslinked materials via recognition of amino acids by cucurbit[8]uril.
MJ Rowland, EA Appel, RJ Coulston, OA Scherman – J Mater Chem B (2013) 1, 2904
Host–guest accelerated photodimerisation of anthracene-labeled macromolecules in water
F Biedermann, I Ross, OA Scherman – Polymer Chemistry (2014) 5, 5375
Ultrahigh-water-content supramolecular hydrogels exhibiting multistimuli responsiveness.
EA Appel, XJ Loh, ST Jones, F Biedermann, CA Dreiss, OA Scherman – J Am Chem Soc (2012) 134, 11767
Sustained release of proteins from high water content supramolecular polymer hydrogels
EA Appel, XJ Loh, ST Jones, CA Dreiss, OA Scherman – Biomaterials (2012) 33, 4646
Supramolecular Cross-Linked Networks via Host-Guest Complexation with Cucurbit[8]uril
EA Appel, F Biedermann, U Rauwald, ST Jones, JM Zayed, OA Scherman – Journal of the American Chemical Society (2010) 132, 14251