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  • Currently displaying 201 - 220 of 1100 publications
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature Communications
(2022)
13,
5512
(doi: 10.1038/s41467-022-33252-6)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature communications
(2022)
13,
5512
(doi: 10.1038/s41467-022-33252-6)
Influence of denaturants on amyloid β42 aggregation kinetics
T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
– Frontiers in neuroscience
(2022)
16,
943355
(doi: 10.3389/fnins.2022.943355)
A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma - Mass spectrometry.
E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, SA Pergantis
– Anal Chim Acta
(2022)
1229,
340342
(doi: 10.1016/j.aca.2022.340342)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, EI Fedotova, AV Berezhnov, S De, CJ Peddie, D Athauda, GS Virdi, W Zhang, JR Evans, AI Wernick, ZS Zanjani, PR Angelova, N Esteras, AY Vinokurov, K Morris, K Jeacock, L Tosatto, D Little, P Gissen, DJ Clarke, T Kunath, L Collinson, D Klenerman, AY Abramov, MH Horrocks, S Gandhi
– Nature neuroscience
(2022)
25,
1134
(doi: 10.1038/s41593-022-01140-3)
Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
– Nature protocols
(2022)
17,
2570
(doi: 10.1038/s41596-022-00730-6)
resPAINT: Accelerating Volumetric Super-Resolution Localisation Microscopy by Active Control of Probe Emission.
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
– Angew Chem Weinheim Bergstr Ger
(2022)
134,
e202206919
(doi: 10.1002/ange.202206919)
resPAINT: Accelerating Volumetric Super-Resolution Localisation Microscopy by Active Control of Probe Emission
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
– Angewandte Chemie (International ed. in English)
(2022)
61,
e202206919
(doi: 10.1002/anie.202206919)
Analytical Solution to the Flory–Huggins Model
D Qian, TCT Michaels, TPJ Knowles
– The journal of physical chemistry letters
(2022)
13,
7853
(doi: 10.1021/acs.jpclett.2c01986)
Uncovering the universality of self-replication in protein aggregation and its link to disease.
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
– Science advances
(2022)
8,
eabn6831
(doi: 10.1126/sciadv.abn6831)
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
– Nature Structural and Molecular Biology
(2022)
29,
831
(doi: 10.1038/s41594-022-00814-7)
DNA-Liposome Hybrid Carriers for Triggered Cargo Release.
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
– ACS Applied Bio Materials
(2022)
5,
3713
(doi: 10.1021/acsabm.2c002253713)
Structure-specific amyloid precipitation in biofluids.
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
– Nature chemistry
(2022)
14,
1045
(doi: 10.1038/s41557-022-00976-3)
Recent Advances in Microgels: From Biomolecules to Functionality
Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
(2022)
18,
e2200180
(doi: 10.1002/smll.202200180)
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2202222119
(doi: 10.1073/pnas.2202222119)
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease
G Meisl, TPJ Knowles, D Klenerman
– Frontiers in Neuroscience
(2022)
16,
909861
(doi: 10.3389/fnins.2022.909861)
Aging can transform single-component protein condensates into multiphase architectures.
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
– Proceedings of the National Academy of Sciences
(2022)
119,
e2119800119
(doi: 10.1073/pnas.2119800119)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
JX Meng, Y Zhang, D Saman, AM Haider, S De, JC Sang, K Brown, K Jiang, J Humphrey, L Julian, E Hidari, SF Lee, G Balmus, RA Floto, CE Bryant, JLP Benesch, Y Ye, D Klenerman
– Nat Commun
(2022)
13,
2692
(doi: 10.1038/s41467-022-30461-x)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
JX Meng, Y Zhang, D Saman, AM Haider, S De, JC Sang, K Brown, K Jiang, J Humphrey, L Julian, E Hidari, SF Lee, G Balmus, RA Floto, C Bryant, JLP Benesch, Y Ye, D Klenerman
– Nature Communications
(2022)
13,
(doi: 10.1038/s41467-022-30461-x)
Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers.
TCT Michaels, AJ Dear, SIA Cohen, M Vendruscolo, TPJ Knowles
– The Journal of Chemical Physics
(2022)
156,
164904
(doi: 10.1063/5.0077609)

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