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Centre for Experimental Biophysical Chemistry

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  • Currently displaying 721 - 740 of 1100 publications
Oligomers of heat-shock proteins: Structures that don't imply function
WM Jacobs, TPJ Knowles, D Frenkel
(2015)
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Analytical chemistry
(2015)
87,
8818
Force generation by the growth of amyloid aggregates.
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
9524
Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
– Journal of Chemical Physics
(2015)
143,
054901
Molecular Rotors Provide Insights into Microscopic Structural Changes during Protein Aggregation
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
– The Journal of Physical Chemistry B
(2015)
119,
10170
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.
AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, D Klenerman, S Gandhi, DM Turnbull, AY Abramov
– Cell Death & Disease
(2015)
6,
e1820
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.
DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, BL Winters, D-H Kim, E Kim, P St George-Hyslop, D Klenerman, GL Collingridge, J Jo, K Cho
– Scientific Reports
(2015)
5,
10934
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
– ACS Nano
(2015)
9,
5772
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
– PloS one
(2015)
10,
e0127730
Aggregation‐Prone Amyloid‐β⋅CuII Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
– ChemBioChem
(2015)
16,
1293
The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
– Chem Sci
(2015)
6,
4215
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature communications
(2015)
6,
7025
Preventing peptide and protein misbehavior.
P Arosio, G Meisl, M Andreasen, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
5267
Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, MM Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, GE De, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
E1994
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
E1994
On-demand delivery of single DNA molecules using nanopipets
AP Ivanov, P Actis, P Jönsson, D Klenerman, Y Korchev, JB Edel
– ACS nano
(2015)
9,
3587
Lipid peroxidation is essential for α-synuclein-induced cell death
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
– Journal of Neurochemistry
(2015)
133,
582
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
– Nature Structural and Molecular Biology
(2015)
22,
207
Lipid peroxidation is essential for α-synuclein-induced cell death
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
– J Neurochem
(2015)
133,
582
The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
– Physics Today
(2015)
68,
36