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Currently displaying 681 - 700 of 1104 publications

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, J DeFelipe, D Fricker, MV Kopanitsa, RR Duncan, D Klenerman, NH Komiyama, SF Lee, SGN Grant

– Sci Rep

(2016)

24626

(doi: 10.1038/srep24626)

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.

JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews

– Sci Rep

(2016)

24656

(doi: 10.1038/srep24656)

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga

– Molecular cell

(2016)

62,

272

(doi: 10.1016/j.molcel.2016.03.017)

A general reaction network unifies the aggregation behaviour of the A$\beta$42 peptide and its variants

G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles

(2016)

(doi: 10.48550/arxiv.1604.00828)

Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.

P Arosio, T Cedervall, TPJ Knowles, S Linse

– Analytical Biochemistry

(2016)

504,

(doi: 10.1016/j.ab.2016.03.015)

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.

P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles

– Nature Communications

(2016)

10948

(doi: 10.1038/ncomms10948)

Initiation of T cell signaling by CD45 segregation at 'close contacts'

VT Chang, RA Fernandes, KA Ganzinger, SF Lee, C Siebold, J McColl, P Jönsson, M Palayret, K Harlos, CH Coles, EY Jones, Y Lui, E Huang, RJC Gilbert, D Klenerman, AR Aricescu, SJ Davis

– Nature Immunology

(2016)

17,

574

(doi: 10.1038/ni.3392)

Ca2+ is a key factor in α-synuclein-induced neurotoxicity.

PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov

– Journal of Cell Science

(2016)

129,

1792

(doi: 10.1242/jcs.180737)

Quantitative thermophoretic study of disease-related protein aggregates.

M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell

– Scientific Reports

(2016)

22829

(doi: 10.1038/srep22829)

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles

– Analytical chemistry

(2016)

88,

3488

(doi: 10.1021/acs.analchem.5b02930)

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.

EV Yates, G Meisl, TPJ Knowles, CM Dobson

– The journal of physical chemistry. B

(2016)

120,

2087

(doi: 10.1021/acs.jpcb.5b09663)

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo

– ACS combinatorial science

(2016)

18,

144

(doi: 10.1021/acscombsci.5b00129)

Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function

WM Jacobs, TPJ Knowles, D Frenkel

– PLoS Computational Biology

(2016)

12,

e1004756

(doi: 10.1371/journal.pcbi.1004756)

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.

E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln

– Physical review letters

(2016)

116,

078101

(doi: 10.1103/physrevlett.116.078101)

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman

– Proc Natl Acad Sci U S A

(2016)

113,

e1206

(doi: 10.1073/pnas.1524128113)

Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease

J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo

– Sci Adv

(2016)

e1501244

(doi: 10.1126/sciadv.1501244)

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.

MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman

– ACS Chemical Neuroscience

(2016)

399

(doi: 10.1021/acschemneuro.5b00324)