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  • Currently displaying 541 - 560 of 1099 publications
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nat Chem
(2018)
10,
673
(doi: 10.1038/s41557-018-0031-x)
OP-36 Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
PR Angelova, M-L Choi, MH Horrocks, D Klenerman, S Gandhi, AY Abramov
– Free Radical Biology and Medicine
(2018)
120,
S40
(doi: 10.1016/j.freeradbiomed.2018.04.137)
Weighing one protein with light
SF Lee, D Klenerman
– Science
(2018)
360,
378
(doi: 10.1126/science.aat5851)
Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows
– Cell
(2018)
(doi: 10.1016/j.cell.2018.03.056)
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.
D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue
– Nature protocols
(2018)
13,
1034
(doi: 10.1038/nprot.2018.017)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
– Cell
(2018)
173,
720
(doi: 10.1016/j.cell.2018.03.056)
Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
– Adv Healthc Mater
(2018)
7,
e1701485
(doi: 10.1002/adhm.201701485)
Anharmonic acoustic effects during DNA hybridization on an electrochemical quartz crystal resonator
S Swarbrick, I Efimov, VP Ostanin, D Klenerman, A Stolzing, SK Ghosh
– Electrochimica Acta
(2018)
269,
526
(doi: 10.1016/j.electacta.2018.03.014)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
– ACS Chem Neurosci
(2018)
9,
1276
(doi: 10.1021/acschemneuro.8b00094)
Biophotonics of Native Silk Fibrils
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromolecular Bioscience
(2018)
18,
e1700295
(doi: 10.1002/mabi.201700295)
Correction to ‘Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species’
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Gandhi, SE Bohndiek, TN Snaddon, SF Lee
– Royal Society Open Science
(2018)
5,
180308
(doi: 10.1098/rsos.180308)
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
10,
523
(doi: 10.1038/s41557-018-0023-x)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
– Journal of Biological Chemistry
(2018)
293,
4486
(doi: 10.1074/jbc.m117.813865)
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
– Angewandte Chemie
(2018)
130,
4980
(doi: 10.1002/ange.201710779)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
– ACS Chem Biol
(2018)
13,
636
(doi: 10.1021/acschembio.7b01039)
Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Saric, TPJ Knowles
(2018)
(doi: 10.48550/arxiv.1803.04851)
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
– The FEBS Journal
(2018)
285,
3604
(doi: 10.1111/febs.14409)
Capturing resting T cells: the perils of PLL
AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee
– Nat Immunol
(2018)
19,
203
(doi: 10.1038/s41590-018-0048-8)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annual review of physical chemistry
(2018)
69,
273
(doi: 10.1146/annurev-physchem-050317-021322)
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
– Analytical Chemistry
(2018)
90,
3849
(doi: 10.1021/acs.analchem.7b04523)

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