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  • Currently displaying 41 - 60 of 1105 publications
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
– Biophysics reviews
(2025)
6,
011303
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments.
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
– Biophys J
(2025)
124,
778
(doi: 10.1016/j.bpj.2025.01.018)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
– Cell chemical biology
(2025)
32,
338
(doi: 10.1016/j.chembiol.2025.01.001)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2025)
122,
e2401307122
(doi: 10.1073/pnas.2401307122)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
– Nature chemical biology
(2025)
21,
883
(doi: 10.1038/s41589-024-01811-1)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
– Chembiochem
(2025)
26,
e202400877
(doi: 10.1002/cbic.202400877)
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
– Sustainable Food Technology
(2025)
3,
689
(doi: 10.1039/d4fb00375f)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
– Molecular cell
(2024)
85,
585
(doi: 10.1016/j.molcel.2024.11.039)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical chemistry
(2024)
97,
290
(doi: 10.1021/acs.analchem.4c04188)
Liquid–liquid phase separation in hepatocellular carcinoma
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
– Frontiers in Cell and Developmental Biology
(2024)
12,
1454587
(doi: 10.3389/fcell.2024.1454587)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TPJ Knowles, J Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
– ACS Chem Neurosci
(2024)
16,
40
(doi: 10.1021/acschemneuro.4c00684)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
– Brain communications
(2024)
7,
fcae454
(doi: 10.1093/braincomms/fcae454)
Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay.
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
– ACS Chem Neurosci
(2024)
15,
4383
(doi: 10.1021/acschemneuro.4c00312)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications.
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
– Chem Sci
(2024)
16,
670
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway.
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
– Nature communications
(2024)
15,
10038
(doi: 10.1038/s41467-024-54212-2)
Dynamically arrested condensate fusion creates complex structures with varying material properties
N Erkamp, I Sanchez-Burgos, A Zhou, T Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, D Weitz, J Espinosa, T Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
D Klenerman
– Nat Commun
(2024)
15,
9690
(doi: 10.1038/s41467-024-53547-0)
Global kinetic model of lipid-inducedα-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, A Dear, D Voderholzer, G Meisl, R Guido, C Galvagnion, A Buell, TPJ Knowles, M Vendruscolo, TCT Michaels
(2024)
(doi: 10.1101/2024.11.07.622437)

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