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  • Currently displaying 281 - 300 of 1107 publications
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2021)
118,
e2108790118
(doi: 10.1073/pnas.2108790118|1of8)
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase-separated microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
– Advanced Materials Interfaces
(2021)
8,
2101071
(doi: 10.1002/admi.202101071)
New Frontiers for Machine Learning in Protein Science.
AS Morgunov, KL Saar, M Vendruscolo, TPJ Knowles
– Journal of molecular biology
(2021)
433,
167232
(doi: 10.1016/j.jmb.2021.167232)
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.
SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman
– Chembiochem
(2021)
22,
2867
(doi: 10.1002/cbic.202100285)
Unraveling the Physicochemical Determinants of Protein Liquid-liquid Phase Separation by Nanoscale Infrared Vibrational Spectroscopy.
FS Ruggeri, AM Miller, M Vendruscolo, TPJ Knowles
– Bio Protoc
(2021)
11,
e4122
(doi: 10.21769/BioProtoc.4122)
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease.
E Lobanova, D Whiten, FS Ruggeri, CG Taylor, A Kouli, Z Xia, D Emin, YP Zhang, JYL Lam, CH Williams-Gray, D Klenerman
– Brain : a journal of neurology
(2021)
145,
632
(doi: 10.1093/brain/awab306)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021)
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
– Advanced Materials
(2021)
33,
2170258
(doi: 10.1002/adma.202170258)
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation.
J Wen, L Hong, G Krainer, Q-Q Yao, TPJ Knowles, S Wu, S Perrett
– Journal of the American Chemical Society
(2021)
143,
13056
(doi: 10.1021/jacs.1c03078)
Feedback control of protein aggregation.
AJ Dear, TCT Michaels, TPJ Knowles, L Mahadevan
– J Chem Phys
(2021)
155,
064102
(doi: 10.1063/5.0055925)
Quantum Emitter Localization in Layer-Engineered Hexagonal Boron Nitride
JC Stewart, Y Fan, JSH Danial, A Goetz, AS Prasad, OJ Burton, JA Alexander-Webber, SF Lee, SM Skoff, V Babenko, S Hofmann
– ACS nano
(2021)
15,
13591
(doi: 10.1021/acsnano.1c04467)
Noncontact Nanoscale Imaging of Cells.
D Klenerman, Y Korchev, P Novak, A Shevchuk
– Annu Rev Anal Chem (Palo Alto Calif)
(2021)
14,
347
(doi: 10.1146/annurev-anchem-091420-120101)
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
M Emmenegger, E De Cecco, M Hruska-Plochan, T Eninger, MM Schneider, M Barth, E Tantardini, P de Rossi, M Bacioglu, RG Langston, A Kaganovich, N Bengoa-Vergniory, A Gonzalez-Guerra, M Avar, D Heinzer, R Reimann, LM Häsler, TW Herling, NS Matharu, N Landeck, K Luk, R Melki, PJ Kahle, S Hornemann, TPJ Knowles, MR Cookson, M Polymenidou, M Jucker, A Aguzzi
– EMBO Mol Med
(2021)
13,
emmm202114745
(doi: 10.15252/emmm.202114745)
Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S Fiedler, V Denninger, A Morgunov, A Ilsley, R Worth, G Meisl, C Xu, M Piziorska, F Ricci, A Malik, S Devenish, M Schneider, V Kosmoliaptsis, A Aguzzi, A Iwasaki, H Fiegler, T Knowles
(2021)
2021.07.23.453327
(doi: 10.1101/2021.07.23.453327)
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
V Denninger, C Xu, G Meisl, A Morgunov, S Fiedler, A Ilsley, M Emmenegger, A Malik, M Piziorska, M Schneider, S Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, T Knowles
(2021)
2021.07.23.453352
(doi: 10.1101/2021.07.23.453352)
Liquid-Liquid Phase-Separated Systems from Reversible Gel-Sol Transition of Protein Microgels.
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
– Adv Mater
(2021)
33,
e2008670
(doi: 10.1002/adma.202008670)
The unhappy chaperone.
S Linse, K Thalberg, TPJ Knowles
– QRB discovery
(2021)
2,
e7
(doi: 10.1017/qrd.2021.5)
Protein Conjugation by Electrophilic Alkynylation Using 5‑(Alkynyl)dibenzothiophenium Triflates
V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes
– Bioconjugate Chemistry
(2021)
32,
1570
(doi: 10.1021/acs.bioconjchem.1c00317)
Biomembranes in bioelectronic sensing.
AK Jayaram, AM Pappa, S Ghosh, ZA Manzer, WC Traberg, TPJ Knowles, S Daniel, RM Owens
– Trends in biotechnology
(2021)
40,
107
(doi: 10.1016/j.tibtech.2021.06.001)
Soluble inflammatory Aβ-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease
DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, E Lobanova, H Dakin, S De, A Miller, JC Sang, TPJ Knowles, M Vendruscolo, G Fraser, D Crowther, D Klenerman
– Brain Communications
(2021)
3,
fcab147-
(doi: 10.1093/braincomms/fcab147)
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, R Cascella, A Bigi, LR Sasser, NR Block, AK Wright, RP Kreiser, ET Custy, G Meisl, S Errico, J Habchi, P Flagmeier, T Kartanas, JE Hollows, LT Nguyen, K LeForte, D Barbut, JR Kumita, C Cecchi, M Zasloff, TPJ Knowles, CM Dobson, F Chiti, M Vendruscolo
– Front Neurosci
(2021)
15,
680026
(doi: 10.3389/fnins.2021.680026)

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